@misc{10481/47233,
year = {2017},
month = {1},
url = {http://hdl.handle.net/10481/47233},
abstract = {Mitochondrial ferritin (FtMt) is a functional ferritin targeted to mitochondria that is highly expressed in the testis. To investigate the role of FtMt in the testis we set up a series of controlled matings between FtMt gene-deletion mice (FtMt–/–) with FtMt+/+ mice. We found that the number of newborns per litter and the fertility rate were strongly reduced for the FtMt–/– males, but not for the females, indicating that FtMt has an important role for male fertility. The morphology of the testis and of the spermatozoa of FtMt–/– mice was normal and we did not detect alterations in sperm parameters or in oxidative stress indices. In contrast, we observed that the cauda epididymides of FtMt–/– mice were significantly lighter and contained a lower number of spermatozoa compared with the controls. Also, the ATP content of FtMt–/– spermatozoa was found to be lower than that of FtMt+/+ spermatozoa. These data show that FtMt contributes to sperm epididymis maturation and to male fertility.},
organization = {The work was partially supported by MIUR grant PRIN10–11 to P. A. and by Telethon grant GGP1099 to P. A.},
publisher = {CSIRO Publishing},
keywords = {ATP},
keywords = {Spermatogenesis},
keywords = {Ferritin},
keywords = {Mitochondrial ferritin},
keywords = {Sperm motility},
title = {Mitochondrial ferritin deficiency reduces male fertility in mice},
doi = {10.1071/RD16348},
author = {Maccarinelli, Federica and Regoni, Maria and Carmona Rodríguez-Acosta, Fernando and Poli, Maura and Meyron-Holtz, Esther G. and Arosio, Paolo},
}