@misc{10481/44397,
year = {2016},
url = {http://hdl.handle.net/10481/44397},
abstract = {In the last decades, we have witnessed a revolution in the field of genetics of
Parkinson’s disease (PD), a movement disorder caused by the progressive loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc). The discovery
of deleterious mutations and genetic risk variants in familial and sporadic PD cases
respectively, has increased our knowledge about the possible molecular pathways
involved on its pathogenesis. This substantial progress has helped us to better
understand such devastating disease, and although the route to PD diseasemodifying
drugs is still long, it will hopefully be an achievable future goal.
This study aims to elucidate the genetic architecture of familial and sporadic
PD in Southern Spain, assessing in detail a population that has so far been poorly
studied in this context.},
organization = {Tesis Univ. Granada. Programa Oficial de Doctorado en: Biomedicina},
organization = {FPU12-01885. Beca-Contrato del Programa de Formación de Profesorado
Universitario (FPU) (2013-2017)},
organization = {Project WT089698/Z/09/Z: Medical Research Council (London, UK) and
Welcome Trust Strategic Award.},
organization = {Project ZO1 AG000949: Intramural Research Program of the National
Institute on Aging, National Institutes of Health (NIH) (part of the
Department of Health and Human Services, USA).},
publisher = {Universidad de Granada},
keywords = {Enfermedad de Parkinson},
keywords = {Patogénesis},
keywords = {Citogenética humana},
keywords = {Transformación genética},
keywords = {Diagnóstico},
keywords = {Andalucía},
title = {Genetic basis of Parkinson's disease in southern Spain},
author = {Bandrés Ciga, Sara},
}