@misc{10481/37252,
year = {2015},
url = {http://hdl.handle.net/10481/37252},
abstract = {Background:

Undernutrition and inflammation are related in many ways; for instance, non-hygienic environments are associated with both poor growth and immunostimulation in children.},
abstract = {Objective:

To describe any existing interaction among different inflammation biomarkers measured in the distinct anatomical compartments of whole blood, feces, plasma and saliva.},
abstract = {Methods:

In this descriptive, cross-sectional study, samples of whole blood, feces, plasma and saliva were collected on the 8th and last week of observation among 87 attendees (42 girls and 45 boys) of 3 daycare centers offering a common 40-day rotating menu in Guatemala’s Western Highlands. Analyses included white blood cell count (WBC), fecal calprotectin, and plasmatic and salivary cytokines including IL-1B, IL-6, IL-8, IL-10 and TNF-α. Associations were assessed using Spearman rank-order and goodness-of-fit correlations, as indicated, followed by backwards-elimination multiple regression analyses to determine predictor variables for IL-10 in both anatomical compartments.},
abstract = {Results:

Of a total of 66 cross-tabulations in the Spearman hemi-matrix, 22 (33%) were significantly associated. All 10 paired associations among the salivary cytokines had a significant r value, whereas 7 of 10 possible associations among plasma cytokines were significant. Associations across anatomical compartments, however, were rarely significant. IL-10 in both biological fluids were higher than corresponding reference values. When a multiple regression model was run in order to determine independent predictors for IL-10 in each anatomical compartment separately, IL-6, IL-8 and TNF-α emerged as predictors in plasma (r2 = 0.514) and IL-1B, IL-8 and TNF-α remained as independent predictors in saliva (r2 = 0.762). Significant cross-interactions were seen with WBC, but not with fecal calprotectin.},
abstract = {Conclusion:

Interactions ranged from robust within the same anatomical compartment to limited to nil across distinct anatomical compartments. The prominence of the anti-inflammatory cytokine, IL-10, in both plasma and saliva is consistent with its counter-regulatory role facing a broad front of elevated pro-inflammatory cytokines in the same compartment.},
organization = {Studies were funded by the Hildegard Grunow Foundation, Munich, Germany and the Department of Biochemistry and Molecular Biology II from Granada University, Granada, Spain.},
publisher = {Public Library of Science (PLOS)},
keywords = {Cytokines},
keywords = {Blood plasma},
keywords = {Biomarkers},
keywords = {Saliva},
keywords = {Inflammation},
keywords = {Children},
keywords = {White blook cells},
keywords = {Cell enumeration techniques},
title = {Associations among Inflammatory Biomarkers in the Circulating, Plasmatic, Salivary and Intraluminal Anatomical Compartments in Apparently Healthy Preschool Children from the Western Highlands of Guatemala},
doi = {10.1371/journal.pone.0129158},
author = {Soto-Méndez, María José and Romero-Abal, María Eugenia and Aguilera García, María Eugenia and Cruz Rico, María and Solomons, Noel W. and Schümann, Klaus and Gil Hernández, Ángel},
}