@misc{10481/35776,
year = {2014},
url = {http://hdl.handle.net/10481/35776},
abstract = {Background

Besides serum levels of PSA, there is a lack of prostate cancer specific biomarkers. It is need to develop new biological markers associated with the tumor behavior which would be valuable to better individualize treatment. The aim of this study was to elucidate the relationship between single nucleotide polymorphisms (SNPs) in genes involved in DNA repair and prostate cancer progression.},
abstract = {Methods

A total of 494 prostate cancer patients from a Spanish multicenter study were genotyped for 10 SNPs in XRCC1, ERCC2, ERCC1, LIG4, ATM and TP53 genes. The SNP genotyping was made in a Biotrove OpenArray® NT Cycler. Clinical tumor stage, diagnostic PSA serum levels, and Gleason score at diagnosis were obtained for all participants. Genotypic and allelic frequencies were determined using the web-based environment SNPator.},
abstract = {Results

SNPs rs11615 (ERCC1) and rs17503908 (ATM) appeared as risk factors for prostate cancer aggressiveness. Patients wild homozygous for these SNPs (AA and TT, respectively) were at higher risk for developing cT2b – cT4 (OR = 2.21 (confidence interval (CI) 95% 1.47 – 3.31), p < 0.001) and Gleason scores ≥ 7 (OR = 2.22 (CI 95% 1.38 – 3.57), p < 0.001), respectively. Moreover, those patients wild homozygous for both SNPs had the greatest risk of presenting D’Amico high-risk tumors (OR = 2.57 (CI 95% 1.28 – 5.16)).},
abstract = {Conclusions

Genetic variants at DNA repair genes are associated with prostate cancer progression, and would be taken into account when assessing the malignancy of prostate cancer.},
organization = {This work was subsidized by a grant from the Instituto de Salud Carlos III (Ministerio de Economía y Competitividad from Spain), ID: PI12/01867. Almudena Valenciano has a grant from the Instituto Canario de Investigación del Cáncer (ICIC).},
publisher = {Biomed Central},
keywords = {Single nucleotide polymorphism},
keywords = {ERCC1},
keywords = {ATM},
keywords = {Prostate cancer},
keywords = {OpenArray},
keywords = {DNA repair},
keywords = {Spanish cohort},
title = {Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression},
doi = {10.1186/s12881-014-0143-0},
author = {Henríquez-Hernández, Luis Alberto and Valenciano, Almudena and Foro-Arnalot, Palmira and Álvarez Cubero, María Jesús and Cózar Olmo, José Manuel and Suárez-Novo, José Francisco and Castells-Esteve, Manel and Fernández-Gonzalo, Pablo and De-Paula-Carranza, Belén and Ferrer, Montse and Guedea, Ferrán and Sancho-Pardo, Gemma and Craven-Bartle, Jordi and Ortiz-Gordillo, María José and Cabrera-Roldán, Patricia and Herrera-Ramos, Estefanía and Rodríguez-Gallego, Carlos and Rodríguez-Melcon, Juan Ignacio and Lara, Pedro C.},
}