@misc{10481/35708,
year = {2015},
url = {http://hdl.handle.net/10481/35708},
abstract = {Background. The aim of our work was to replicate, in a Southern European population, the association reported in Northern populations between PTPRC locus and response to anti-tumor necrosis factor (anti-TNF) treatment in rheumatoid arthritis (RA). We also looked at associations between five RA risk alleles and treatment response. Methods. We evaluated associations between anti-TNF treatment responses assessed by DAS28 change and by EULAR response at six months in 383 Portuguese patients. Univariate and multivariate linear and logistic regression analyses were performed. In a second step to confirm our findings, we pooled our population with 265 Spanish patients. Results. No association was found between PTPRC rs10919563 allele and anti-TNF treatment response, neither in Portuguese modeling for several clinical variables nor in the overall population combining Portuguese and Spanish patients. The minor allele for RA susceptibility, rs3761847 SNP in TRAF1/C5 region, was associated with a poor response in linear and logistic univariate and multivariate regression analyses. No association was observed with the other allellic variants. Results were confirmed in the pooled analysis. Conclusion. This study did not replicate the association between PTPRC and the response to anti-TNF treatment in our Southern European population. We found that TRAF1/C5 risk RA variants potentially influence anti-TNF treatment response.},
organization = {This work was supported by a grant from Harvard-Portugal Program HMSP-ICS/SAU-ICT/0002/2010. Daniel H. Solomon received support for this work from the NIH (K24-AR-055989). Elizabeth W. Karlson received support for this work from NIH (K24-AR-AR0524). Reuma.pt received unrestricted grants from Abbott, Bristol-Myers Squibb, Merck Sharp and Dohme, Pfizer, Roche, and UCB Pharma.},
publisher = {Hindawi Publishing Corporation},
keywords = {Rheumatoid arthritis},
keywords = {Anti-tumor necrosis factor (anti-TNF)},
keywords = {Southern European},
keywords = {PTPRC locus},
title = {TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy},
doi = {10.1155/2015/490295},
author = {Canhão, Helena and Rodrigues, Ana Maria and Santos, María José and Carmona-Fernandes, Diana and Bettencourt, Bruno F. and Cui, Jing and Rocha, Fabiana L. and Canas Silva, José and Polido-Pereira, Joaquim and Pereira Silva, José Alberto and Costa, José Antonio and Araujo, Domingos and Silva, Cândida and Santos, Helena and Duarte, Cátia and Cáliz, Rafael and Filipescu, Ileana and Pimentel-Santos, Fernando and Branco, Jaime and Sáinz Pérez, Juan and Plenge, Robert M. and Solomon, Daniel H. and Bruges-Armas, Jácome and Da Silva, José Antonio P. and Eurico Fonseca, João and Karlson, Elizabeth W.},
}