@misc{10481/32890,
year = {2014},
url = {http://hdl.handle.net/10481/32890},
abstract = {Strawberry bioactive compounds are widely known to be powerful antioxidants. In this study, the antioxidant and anti-aging activities of a polyphenol-rich strawberry extract were evaluated using human dermal fibroblasts exposed to H2O2. Firstly, the phenol and flavonoid contents of strawberry extract were studied, as well as the antioxidant capacity. HPLC-DAD analysis was performed to determine the vitamin C and β-carotene concentration, while HPLC-DAD/ESI-MS analysis was used for anthocyanin identification. Strawberry extract presented a high antioxidant capacity, and a relevant concentration of vitamins and phenolics. Pelargonidin- and cyanidin-glycosides were the most representative anthocyanin components of the fruits. Fibroblasts incubated with strawberry extract and stressed with H2O2 showed an increase in cell viability, a smaller intracellular amount of ROS, and a reduction of membrane lipid peroxidation and DNA damage. Strawberry extract was also able to improve mitochondrial functionality, increasing the basal respiration of mitochondria and to promote a regenerative capacity of cells after exposure to pro-oxidant stimuli. These findings confirm that strawberries possess antioxidant properties and provide new insights into the beneficial role of strawberry bioactive compounds on protecting skin from oxidative stress and aging.},
publisher = {MDPI},
keywords = {Strawberry},
keywords = {Anthocyanin},
keywords = {ROS},
keywords = {Lipid peroxidation},
keywords = {DNA damage},
keywords = {Fibroblasts},
title = {Polyphenol-Rich Strawberry Extract Protects Human Dermal Fibroblasts against Hydrogen Peroxide Oxidative Damage and Improves Mitochondrial Functionality},
doi = {10.3390/molecules19067798},
author = {Giampieri, Francesca and Álvarez-Suárez, José M. and Mazzoni, Luca and Forbes Hernández, Tamara Yuliett and Gasparrini, Massimiliano and González-Paramás, Ana M. and Santos-Buelga, Celestino and Quiles Morales, José Luis and Bompadre, Stefano and Mezzetti, Bruno and Battino, Maurizio},
}