@misc{10481/32804,
year = {2008},
url = {http://hdl.handle.net/10481/32804},
abstract = {Introduction: This study was designed to compare the plasma lipid peroxidation
(LPO) levels in preterm and full-term neonates and their respective mothers, to
assess their relationship with the degree of oxidative stress and the levels of
vitamin C, an important antioxidant of the body.
Material and methods: The studied groups included 70 neonates, 30 preterm
(24-36 weeks of gestation) and 40 full-term (37-42 weeks) neonates. Blood samples
were obtained from the cord blood in neonates and from the antecubital vein in
their mothers at the time of delivery. Plasma susceptibility to LPO was
fluorometrically measured before and after its incubation with 2,2'-azobis-2-
amidinopropane hydrochloride (AAPH). Plasma vitamin C level was measured
by HPLC.
Results: The basal LPO levels were similar in all groups of patients. After AAPH
incubation, however, plasma LPO significantly (P<0.0001) increased in all groups,
although maternal plasma (full-term, 6.62±0.14 and preterm, 8.76±0.03 mmol/l)
showed higher (P<0.001) levels of LPO than their respective babies
(full-term, 5.11±0.03 and preterm, 7.74±0.15 mmol/l). AAPH-induced LPO was
higher in both maternal and preterm neonates’ plasma than in full-term ones
(P<0.001). Vitamin C levels were similar in maternal plasma of both groups, but
preterm neonates showed higher levels than full-term ones (171.65±9.38
vs. 118.25±2.75 mmol/l respectively, P<0.001).
Conclusions: The results suggest that the preterm group was more prone to LPO
than the full-term group, whereas vitamin C was not correlated with the degree
of oxidative stress.},
organization = {This work was partially supported by grants
G03/137, PI02/1447 and PI03/0817 from Instituto
de Salud Carlos III, Spain, and CTS-101 from
Consejería de Educación, Junta de Andalucía, Spain.},
publisher = {Termedia and Banach},
keywords = {Oxidative stress},
keywords = {Antioxidants},
keywords = {Newborns},
title = {Changes in plasma susceptibility to lipid peroxidation and vitamin C in preterm and full-term neonates},
author = {Agil Abdalla, Mhmad Ahmad and Fraile, Rafael and Acuña Castroviejo, Darío},
}