@misc{10481/30971,
year = {2012},
url = {http://hdl.handle.net/10481/30971},
abstract = {The ACTN3 R577X polymorphism (rs1815739) is a strong candidate to influence elite athletic performance. Yet, controversy exists in the literature owing to between-studies differences in the ethnic background and sample size of the cohorts, the latter being usually low, which makes comparisons difficult. In this case:control genetic study we determined the association between elite athletic status and the ACTN3 R577X polymorphism within three cohorts of European Caucasian men, i.e. Spanish, Polish and Russian [633 cases (278 elite endurance and 355 power athletes), and 808 non-athletic controls]. The odds ratio (OR) of a power athlete harbouring the XX versus the RR genotype compared with sedentary controls was 0.54 [95% confidence interval (CI): 0.34–0.48; P = 0.006]. We also observed that the OR of an endurance athlete having the XX versus the RR genotype compared with power athletes was 1.88 (95%CI: 1.07–3.31; P = 0.028). In endurance athletes, the OR of a “world-class” competitor having the XX genotype versus the RR+RX genotype was 3.74 (95%CI: 1.08–12.94; P = 0.038) compared with those of a lower (“national”) competition level. No association (P>0.1) was noted between the ACTN3 R577X polymorphism and competition level (world-class versus national-level) in power athletes. Our data provide comprehensive support for the influence of the ACTN3 R577X polymorphism on elite athletic performance.},
organization = {This work was supported by the Consejo Superior de Deportes (grant # 001/UPR10/12), Spanish Ministry of Science and Innovation (RYC-2010-05957), Fondo de Investigaciones Sanitarias (ref. # PS09/00194), the Polish Ministry of Science and Higher Education (grant#404166334), and the Ministry of Sport, Tourism and Youth Policy of the Russian Federation.},
publisher = {Public Library of Science (PLOS)},
keywords = {DNA isolation},
keywords = {Fast-twitch muscle fibers},
keywords = {Games},
keywords = {Genotyping},
keywords = {Human performance},
keywords = {Polymerase chain reaction},
keywords = {Spain},
keywords = {Variant genotypes},
title = {The ACTN3 R577X Polymorphism across Three Groups of Elite Male European Athletes},
doi = {10.1371/journal.pone.0043132},
author = {Eynon, Nir and Ruiz Ruiz, Jonatan and Femia Marzo, Pedro Jesús and Pushkarev, Vladimir P. and Cieszczyk, Pawel and Maciejewska-Karlwska, Agnieszka and Sawczuk, Marek and Dyatlow, Dmitry A. and Lekontsev, Evgeny V. and Kulikov, Leonid M. and Bishop, David J. and Lucía, Alejandro},
}