@misc{10481/29536, year = {2013}, url = {http://hdl.handle.net/10481/29536}, abstract = {The easy vinyl sulfone derivatization of ferrocene allows the preparation of some effective, versatile and valuable ferrocenylation reagents. The applicability of such compounds in conjugation and bioconjugation of amine and/or thiol containing molecules and biomolecules through Michael-type addition under mild conditions that preserve the biological function of the latter is described. The feasibility of the methodology is demonstrated by the preparation of a variety of conjugates and bioconjugates (ferrocenyl terminated dendrimers and ferrocene–sugar, ferrocene–cyclodextrin, ferrocene–peptide and ferrocene–protein conjugates).}, organization = {Financial support was provided by Ministerio de Ciencia e Innovación (CTQ2011-29299-CO2-01).}, publisher = {Royal Society Chemistry}, keywords = {Vinyl sulfone}, keywords = {Ferrocene}, keywords = {Synthesis}, title = {Vinyl sulfone-based ferrocenylation reagents: applications in conjugation and bioconjugation}, author = {Megía Fernández, Alicia and Hernández Mateo, Fernando and Santoyo González, Francisco}, }