@misc{10481/27467,
year = {2009},
url = {http://hdl.handle.net/10481/27467},
abstract = {Aceclofenac was microencapsulated using rosin by o/w emulsion solvent evaporation
technique. The effect of three formulation variables including the drug:polymer ratio,
emulsifier (polyvinyl alcohol) concentration and organic solvent (dichloromethane) volume
were examined. The prepared batches were characterized for microspheres particle size
distribution, encapsulation efficiency and in vitro release behavior. The study reveals that
drug:polymer ratio had a considerable effect on the entrapment efficiency, however particle
size distribution of microspheres was more dependent on the volume of dichloromethane and
polyvinyl alcohol concentration rather than on the drug: polymer ratio. Drug, polymer
concentrations were varied to obtain optimum release profile for sustaining the action of the drug.},
publisher = {Universidad de Granada, Facultad de Farmacia},
keywords = {Aceclofenac},
keywords = {Rosin},
keywords = {Microspheres},
keywords = {Sustained release},
title = {Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac},
author = {Lakshmana Prabu, S. and Shirwaikar, A.A. and Shirwaikar, A. and Kumari, A.},
}