@misc{10481/27358,
year = {2010},
url = {http://hdl.handle.net/10481/27358},
abstract = {Objective
In an attempt for better treatment of bacterial infections, various semisolid formulations containing 5%
w/w of norfloxacin were prepared and evaluated for in vitro drug release and in vitro skin permeability
using dialysis membrane and rat abdominal skin respectively. The in vitro diffusion and permeation
profile of the prepared formulation was compared with marketed silver sulfadiazine cream 1%, USP
using model independent approach.
Methods
Various semisolid formulations were prepared with different dermatological bases using
standard procedures. In vitro diffusion and permeation studies were carried out using Keshary-Chein
(KC) type diffusion cell using dialysis membrane and rat abdominal skin respectively.
Results
The f1 lower than 15 and f2 higher than 50 indicated similarities in the in vitro diffusion and
permeation profiles of the extemporaneously prepared selected semisolid formulations and marketed
silver sulfadiazine 1% cream, USP.
Conclusion
Amongst all the semisolid formulations prepared, carbopol gel base was found to be most suitable
dermatological base for norfloxacin, the results obtained for in vitro diffusion, and in vitro skin permeation studies are comparable with that of marketed silver sulphadiazine 1% cream, USP.},
publisher = {Universidad de Granada, Facultad de Farmacia},
keywords = {Semisolid},
keywords = {Ointments},
keywords = {Norfloxacin},
title = {Comparative Investigation on in vitro release of extemporaneously prepared norfloxacin semisolid formulations with marketed silver sulfadiazine 1% cream, USP using model independent approach},
author = {Dua, Kamal and Pabreja, Kavita and Ramana, M.V.},
}