@misc{10481/112333,
year = {2026},
month = {3},
url = {https://hdl.handle.net/10481/112333},
abstract = {A 48-year-old woman was diagnosed with multiple sclerosis (MS) in 2019. She participated
with blood and cerebrospinal fluid samples as a spinal anaesthesia surgery patient for a case–control study
on viruses and MS in 2003. The study had already demonstrated intrathecal antibody synthesis (ITS) to
Epstein-Barr virus (EBV) but not against measles, rubella and varicella-zoster (MRZ) reaction viruses in
this individual at the time of recruitment. A 2025 study review established that she was the only patient in
her control subgroup who also developed MS. This case shows that a specific EBV-ITS may be an early
indicator of a ‘biologically isolated syndrome’ in MS.},
publisher = {Sage Journals},
keywords = {Multiple sclerosis},
keywords = {Epstein-Barr virus},
keywords = {Intrathecal antibody synthesis},
title = {Intrathecal synthesis of Epstein-Barr virus antibodies 15 years before onset of multiple sclerosis},
doi = {10.1177/13524585261427398},
author = {Guerrero Fernández, Manuel Miguel and Serrano Álvarez, Carmen and Fonronda Bengoa, Jesús and Barrero Hernández, Francisco Javier and Sorlozano Puerto, Antonio},
}