@misc{10481/111882,
year = {2026},
month = {3},
url = {https://hdl.handle.net/10481/111882},
abstract = {Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease in which persis
tence of immunological memory underlies disease recurrence and progression toward
atopic comorbidities. Evidence indicates that pathogenic tissue-resident memory T cells
(TRM), including Th2- and Th22-skewed subsets, among others, persist in both lesional
and clinically resolved skin and rapidly re-initiate inflammation through production of
IL-4, IL-13, IL-22 and IL-31, promoting barrier dysfunction and pruritus. In parallel,
circulating CLA+ memory T cells retain skin-homing capacity and contribute to flare reacti
vation, while IgG1+CD23 IL-4Rα+ type-2 memory B cells (MBC2) constitute a reservoir for
high-affinity IgE production, linking cutaneous inflammation with allergic comorbidities.
These adaptive memory compartments are sustained by epithelial alarmins, dendritic
cell–derived chemokines such as CCL17, CCL22 and CCL18, and the OX40/OX40L costim
ulatory pathway, which promotes differentiation, survival and tissue retention of memory T
cells. Clinical and transcriptomic studies show how, although IL-4/IL-13 blockade reduces
circulating type-2 responses, Th2A cells, Tc2 cells and activated dendritic cells can persist
in clinically resolved skin, providing a mechanistic basis for relapse after treatment with
drawal. Together, these findings support the relevance of targeting memory-imprinting
pathways as a promising mechanism to achieve durable disease modification in AD.},
publisher = {MDPI},
keywords = {Atopic dermatitis},
keywords = {Immunological memory},
keywords = {Tissue-resident memory T cells},
title = {MemoryCells in Atopic Dermatitis: Paving the Way to Disease Modification},
doi = {10.3390/ijms27052371},
author = {Dominguez Lopez, Raquel and Aranda Clemente, Carlos José and Gómez de la Fuente, Enrique and Pérez García, Bibiana and Perez Bootello, Javier and Abbad Jaime de Aragon, Carlota and González Cantero, Álvaro and Berna Rico, Emilio},
}