@misc{10481/111321,
year = {2011},
month = {3},
url = {https://hdl.handle.net/10481/111321},
abstract = {Human DNA shows a complex structure with compositional features at many scales; the isochores—long DNA segments (~105 bp) of relatively homogeneous guanine-cytosine (G + C) content—are the largest well-documented and well-analyzed compositional structures. However, we report here on the existence of a high-level compositional organization of isochores in the human genome. By using a segmentation algorithm incorporating the long-range correlations existing in human DNA, we find that every chromosome is composed of a few huge segments (~ 107 bp) of relatively homogeneous G + C content, which become the largest compositional organization of the genome. Finally, we show evidence of the biological relevance of these superstructures, pointing to a large-scale functional organization of the human genome.},
organization = {Spanish Government (BIO2008-01353, PR2009-0285, JC2009-00067, Juan de la Cierva Grant)},
organization = {Spanish Junta de Andalucía (P07-FQM3163, P06-FQM1858)},
organization = {Basque Country},
organization = {Universidad de Málaga},
organization = {Harvard Medical School, Boston, Massachusetts, USA},
organization = {Universidad de Granada},
publisher = {American Physical Society},
title = {High-level organization of isochores into gigantic superstructures in the human genome},
doi = {10.1103/PhysRevE.83.031908},
author = {Carpena, Pedro and Oliver Jiménez, José Lutgardo and Hackenberg, Michael and Coronado, Ana V. and Barturen Briñas, Guillermo and Bernaola-Galván, Pedro},
}