@misc{10481/111285,
year = {2025},
url = {https://hdl.handle.net/10481/111285},
abstract = {OBJECTIVE: To evaluate serum neuronal and inflammatory biomarkers in asphyxiated newborns treated with hypothermia alone or
hypothermia plus melatonin, and whether biomarkers correlate with neurodevelopmental outcomes.
DESIGN: A pilot multicentre, randomized, controlled, double blind clinical trial. 25 newborns were recruited. Neonatal neural
biomarkers were measured in serum samples at hospital admission (T0), 24 h (T1), 72 hours (T2) and 7−10 days of age (T3).
Neurodevelopmental scales were performed at 6 and 18 months. Treated patients received a daily dose of intravenous melatonin,
for 3 days.
RESULTS: In melatonin-treated group, lower plasma levels of GM-CSF, IL-2 and IL-13 at T1 were measured vs placebo-group. We
also corroborated, at T2, lower concentrations of GM-CSF, as well as IL-7 and IL-13 at T3. Throughout the study period, we found a
significant decrease in GM-CSF concentrations in the treatment group. We have also observed sustained decrease over time of GMCSF and inflammatory cytokines IL-2, IL-7 and IL-13 correlates with better neurodevelopmental outcomes at 6 and 18 months.
CONCLUSIONS: In neonates affected by hypoxic-ischemic encephalopathy, the addition of iv melatonin to hypothermia therapy
affects plasma biomarker concentration in the first week of life, with a high correlation with long-term neurological prognosis.},
organization = {Spanish Ministry of Health (EC11-222)},
publisher = {Springer Nature},
keywords = {Hypoxic-ischaemic encephalopathy},
keywords = {Therapeutic hypothermia},
keywords = {Pro-inflammatory biomarkers},
title = {Pro-inflammatory biomarkers and long term neurological outcomes in hypothermia plus melatonin treated asphyxiated newborns. A preliminary approach},
doi = {10.1038/s41390-024-03742-y},
author = {Jerez Calero, Antonio Emilio and Contreras Chova, Francisco and Benítez Feliponi, Ángela and Azaryah, Hatim and Hurtado Suazo, José Antonio and Moreno Galdó, María Fernanda and Molina Carballo, Antonio},
}