@misc{10481/111144,
year = {2023},
month = {4},
url = {https://hdl.handle.net/10481/111144},
abstract = {The pancreatic islets are composed of discrete hormone producing cells that orchestrate systemic glucose homeostasis. Here we identify subsets of β cells using a single-cell transcriptomic approach. One subset of β cells marked by high CD63 expression is enriched for the expression of mitochondrial metabolism genes and exhibit higher mitochondrial respiration compared to CD63lo β cells. Human and murine pseudo-islets derived from CD63hi β cells demonstrate enhanced glucose-stimulated insulin secretion compared to pseudo-islets from CD63lo β cells. We show that CD63hi β cells are diminished in mouse models of and in humans with type 2 diabetes. Finally, transplantation of pseudo-islets generated from CD63hi but not CD63lo β cells into diabetic mice restores glucose homeostasis. These findings suggest that loss of a specific subset of β cells may lead to diabetes. Strategies to reconstitute or maintain CD63hi β cells may represent a potential anti-diabetic therapy.},
publisher = {Springer Nature},
title = {A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes},
doi = {10.1038/s41556-023-01103-1},
author = {Rubio Navarro, Alfonso and Gomez-Banoy, Nicolas and Stoll, Lisa and Dundar, Friederike and Mawla, Alex M and Ma, Lunkun and Cortada, Eric and Zumbo, Paul and Li, Ang and Reiterer, Moritz and Montoya-Oviedo, Nathalia and A Homan, Edwin and Imai, Norihiro and Ankit, Gilani and Liu, Chengyang and Najir, Ali and Yang, Boris and Chi Nok Chong, Angie and Cohen 1, David E and Chen, Shuibing and Cao, Jingli and Pitt, Geoffrey S and Huising, Mark O and Betel, Doron and Lo, James C},
}