@misc{10481/111100,
year = {2026},
month = {1},
url = {https://hdl.handle.net/10481/111100},
abstract = {Introduction: There is limited evidence on the impact of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in patients with 
chronic obstructive pulmonary disease (COPD).
Material and Methods: We conducted a retrospective matched cohort study including patients aged ≥40 years with COPD and T2D. 
Patients initiating GLP-1 RAs were matched 1:1 with GLP-1 naïve controls based on age, sex, smoking status, COPD treatment 
(LABA/LAMA/ICS), and exacerbation history. The index date was defined as the first GLP-1 RA prescription, control’s index date 
was a COPD consultation within 186 days of matched patient index. The primary outcome was the number of COPD exacerbations 
during the 12 months following the index date. Secondary outcomes included oral corticosteroid (OCS) prescriptions and hospital 
resource utilization (HCRU). Poisson regression models adjusted for BMI and other confounders were used to estimate incidence rate 
ratios (IRR).
Results: A total of 4479 matched patients were included. There were no significant differences between groups in exacerbation rates 
or OCS use in the year prior to the index date. During follow-up, patients treated with GLP-1 RAs had significantly fewer 
exacerbations (adjusted IRR [aIRR] 0.84, 95% CI: 0.79–0.89) and fewer OCS prescriptions (aIRR 0.86, 95% CI: 0.77–0.95) compared 
with controls. A significant delay in time to first OCS prescription was also observed.
Conclusion: In this real-world cohort, initiation of GLP-1 RA treatment in patients with COPD and T2D was associated with lower 
COPD exacerbations and OCS use. These findings suggest a potential role for GLP-1 RAs in modifying the course of COPD in this 
comorbid population, warranting randomised trials},
publisher = {Taylor & Francis},
keywords = {COPD},
keywords = {Obesity},
keywords = {COPD outcomes},
title = {The Potential Impact of GLP-1 Receptor Agonists on Exacerbation Risk in Patients with COPD and Type 2 Diabetes: A Real-World Population-Based Observational Study},
doi = {10.2147/por.s550543},
author = {Alcázar Navarrete, Bernardino and Heatley, Heath and Kaplan, Alan and Tze Tan, Lee and Siyue Koh, Mariko and Sattar, Naveed and Townend, John and Skinner, Derek and Carter, Victoria and Price, David},
}