@misc{10481/111034,
year = {2014},
url = {https://hdl.handle.net/10481/111034},
abstract = {Oxidative stress is involved in several processes including cancer, aging and cardiovascular disease, and
has been shown to potentiate the therapeutic effect of drugs such as doxorubicin. Doxorubicin causes
significant cardiotoxicity characterized by marked increases in oxidative stress and mitochondrial
dysfunction. Herein, we investigate whether doxorubicin-associated chronic cardiac toxicity can be
ameliorated with the antioxidant hydroxytyrosol in rats with breast cancer. Thirty-six rats bearing
breast tumors induced chemically were divided into 4 groups: control, hydroxytyrosol (0.5 mg/kg,
5 days/week), doxorubicin (1 mg/kg/week), and doxorubicin plus hydroxytyrosol. Cardiac disturbances
at the cellular and mitochondrial level, mitochondrial electron transport chain complexes I–IV and
apoptosis-inducing factor, and oxidative stress markers have been analyzed. Hydroxytyrosol improved
the cardiac disturbances enhanced by doxorubicin by significantly reducing the percentage of altered
mitochondria and oxidative damage. These results suggest that hydroxytyrosol improve the
mitochondrial electron transport chain. This study demonstrates that hydroxytyrosol protect rat heart
damage provoked by doxorubicin decreasing oxidative damage and mitochondrial alterations.},
organization = {Diputación de Jaén (CEAS Foundation 30.C0.244500)},
organization = {Junta de Andalucía (PI-0210/2007)},
organization = {Spanish Ministry of Science and Innovation (AP2005-144)},
organization = {Spanish Ministry of Science and Innovation (BFU2009-11879/BFI)},
organization = {Spanish Ministry of Health (RD06/0013/0012 and PI081843)},
organization = {Autonomous Government of Catalonia (2009SGR735)},
organization = {European Union ( COST B35 Action)},
publisher = {Elsevier},
keywords = {Oxidative stress},
keywords = {Apoptosis-inducing factor},
keywords = {Electron transport chain},
title = {Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer},
doi = {10.1016/j.bcp.2014.04.001},
author = {Granados Principal, Sergio and El-azem, Nuri and Pamplona, Reinald and Ramírez Tortosa, César Luis and Pulido-Moran, Mario and Vera Ramírez, Laura and Quiles Morales, José Luis and Sanchez-Rovira, Pedro and Naudi, Alba and Portero-Otin, Manuel and Pérez-López, Patricia and Ramírez Tortosa, María Carmen},
}