@misc{10481/110989,
year = {2020},
month = {8},
url = {https://hdl.handle.net/10481/110989},
abstract = {Inherited retinal dystrophies and late-stage age-related macular degeneration, for which treatments remain limited, are among the most prevalent causes of legal blindness. Retinal prostheses have been developed to stimulate the inner retinal network; however, lack of sensitivity and resolution, and the need for wiring or external cameras, have limited their application. Here we show that conjugated polymer nanoparticles (P3HT NPs) mediate light-evoked stimulation of retinal neurons and persistently rescue visual functions when subretinally injected in a rat model of retinitis pigmentosa. P3HT NPs spread out over the entire subretinal space and promote light-dependent activation of spared inner retinal neurons, recovering subcortical, cortical and behavioural visual responses in the absence of trophic effects or retinal inflammation. By conferring sustained light sensitivity to degenerate retinas after a single injection, and with the potential for high spatial resolution, P3HT NPs provide a new avenue in retinal prosthetics with potential applications not only in retinitis pigmentosa, but also in age-related macular degeneration.},
organization = {Italian Ministry of Health RF-2013-02358313},
organization = {Fondazione Cariplo 2018-0505},
organization = {Compagnia di San Paolo (project 9798)},
organization = {H2020-MSCA-ITN 2019 861423},
organization = {EuroNanoMed3 2019-132 “NanoLight”},
organization = {Ra.Mo. Foundation, Rare Partners srl and Fondazione 13 Marzo},
publisher = {Springer Nature},
keywords = {Nanoparticles},
keywords = {Retina},
title = {Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy},
doi = {10.1038/s41565-020-0696-3},
author = {Maya-Vetenocourt, José Fernando and Manfredi, Giovanni and Mete, Maurizio and Colombo, Elisabetta and Bramini, Mattia and Di Marco, Stefano and Shmal, Dmytro and Mantero, Giulia and Dipalo, Michele and Rocchi, Anna and DiFrancesco, Mattia L. and Papaleo, Ermanno D. and Russo, Angela and Barsotti, Jonathan and Eleftheriou, Cyril and Di Maria, Francesca and Cossu, Vanessa and Piazza, Fabio and Emionite, Laura and Ticconi, Flavia and Marini, Cecilia and Sambuceti, Gianmario and Pertile, Grazia and Lanzani, Guglielmo and Benfenati, Fabio},
}