@misc{10481/110817,
year = {2020},
month = {8},
url = {https://hdl.handle.net/10481/110817},
abstract = {Excitation-inhibition (E:I) imbalance is theorized as an important pathophysiological mechanism in autism. Autism affects males more frequently than females and sex-related mechanisms (e.g., X-linked genes, androgen hormones) can influence E:I balance. This suggests that E:I imbalance may affect autism differently in males versus females. With a combination of in-silico modeling and in-vivo chemogenetic manipulations in mice, we first show that a time-series metric estimated from fMRI BOLD signal, the Hurst exponent (H), can be an index for underlying change in the synaptic E:I ratio. In autism we find that H is reduced, indicating increased excitation, in the medial prefrontal cortex (MPFC) of autistic males but not females. Increasingly intact MPFC H is also associated with heightened ability to behaviorally camouflage social-communicative difficulties, but only in autistic females. This work suggests that H in BOLD can index synaptic E:I ratio and that E:I imbalance affects autistic males and females differently.},
organization = {H2020 European Research Council, 755816, 802371},
organization = {Simons Foundation, 602849},
organization = {Medical Research Council, 400061},
publisher = {eLife},
title = {Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women},
doi = {10.7554/eLife.55684},
author = {Trakoshis, Stavros and Martínez-Cañada, Pablo and Rocchi, Federico and Canella, Carola and You, Wonsang and Chakrabarti, Bhismadev and Ruigrok, Amber NV and Bullmore, Edward T and Suckling, John and Markicevic, Marija and Zerbi, Valerio and AIMS Consortium, MRC and Baron-Cohen, Simon and Gozzi, Alessandro and Lai, Meng-Chuan and Panzeri, Stefano and Lombardo, Michael V},
}