@misc{10481/110677,
year = {2019},
month = {4},
url = {https://hdl.handle.net/10481/110677},
abstract = {The long-term effectiveness of antibody responses relies on the development of humoral
immune memory. Humoral immunity is maintained by long-lived plasma cells that
secrete antigen-specific antibodies, and memory B cells that rapidly respond to antigen
re-exposure by generating new plasma cells and memory B cells. Developing effective
immunological memory is essential for protection against pathogens, and is the basis
of successful vaccinations. IgE responses have evolved for protection against helminth
parasites infections and against toxins, but IgE is also a potent mediator of allergic
diseases. There has been a dramatic increase in the incidence of allergic diseases in
recent decades and this has provided the impetus to study the nature of IgE antibody
responses. As will be discussed in depth in this review, the IgE memory response has
unique features that distinguish it from classical B cell memory},
organization = {NIH/NIAID grants R01AI130343 and R21AI133076},
organization = {Department of Medicine of New York
University Medical School (NYUMS)},
organization = {Bernard Levine postdoctoral fellowship (NYUMS)},
organization = {Fundación Ramón Areces postdoctoral fellowship (Spain)},
organization = {Sacker Institute of Graduate
Biomedical Sciences of NYUSM},
publisher = {Frontiers},
keywords = {Allergy},
keywords = {IgE},
keywords = {Memory B cells},
title = {Non-classical B Cell Memory of Allergic IgE Responses},
doi = {10.3389/fimmu.2019.00715},
author = {Saunders, Sean P. and Ma, Erica G. M. and Aranda Clemente, Carlos José and Curotto de Lafaille, María A.},
}