@misc{10481/110615,
year = {2007},
month = {3},
url = {https://hdl.handle.net/10481/110615},
abstract = {Post-translational modification of proteins by poly(ADP-ribosyl)ation is involved in the regulation of a number of biological functions. While an 18 member superfamily of poly(ADP-ribose) polymerases (PARP)s has been described PARP-1 accounts for more than 90% of the poly(ADP-ribosyl)ating capacity of the cells. PARP-1 act as a DNA nick sensor and is activated by DNA breaks to cleave NAD(+) into nicotinamide and ADP-ribose to synthesize long branching poly(ADP-ribose) polymers (PAR) covalently attached to nuclear acceptor proteins. Whereas activation of PARP-1 by mild genotoxic stimuli facilitate DNA repair and cell survival, severe DNA damage triggers different pathways of cell death including PARP-mediated cell death through the translocation of apoptosis inducing factor (AIF) from the mitochondria to the nucleus. PAR and PARP-1 have also been described as having a function in transcriptional regulation through their ability to modify chromatin-associated proteins and as a cofactor of different transcription factors, most notably NF-κB and AP-1. Pharmacological inhibition or genetic ablation of PARP-1 not only provided remarkable protection from tissue injury in various oxidative stress-related disease models but it result in a clear benefit in the treatment of cancer by different mechanisms including selective killing of homologous recombination-deficient tumor cells, down regulation of tumor-related gene expression and decrease in the apoptotic threshold in the co-treatment with chemo and radiotherapy. We will summarize in this review the current findings and concepts for the role of PARP-1 and poly(ADP-ribosyl)ation in the regulation of transcription, oxidative stress and carcinogenesis.},
publisher = {Bentham Science},
keywords = {zinc finger DNA-binding domain},
keywords = {double-strand breaks},
keywords = {DNA Repair},
keywords = {Histone-Modifying Activity},
keywords = {CXCL1 promoter},
keywords = {Inflammatory Diseases},
title = {Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation},
doi = {10.2174/092986707780597998},
author = {Aguilar Quesada, Rocío and Muñoz-Gámez, José Antonio and Martín-Oliva, David and Peralta-Leal, Andreína and Quiles-Pérez, Rosa and Rodríguez-Vargas, José Manuel and Ruiz De Almodóvar Rivera, José Mariano and Conde, C and Ruiz Extremera, Ángeles and Oliver, FJ},
}