@misc{10481/110343,
year = {2020},
month = {2},
url = {https://hdl.handle.net/10481/110343},
abstract = {Background: Despite smoking being a well-established risk
factor for pancreatic cancer, there is a need to further characterize
pancreatic cancer risk according to lifespan smoking
patterns and other smoking features, such as tobacco type. Our
aim was to deeply investigate them within a large European case–
control study.
Methods: Tobacco smoking habits and other relevant information
were obtained from 2,009 cases and 1,532 controls recruited in
the PanGenEU study using standardized tools. Multivariate logistic
regression analysis was performed to evaluate pancreatic cancer risk
by smoking characteristics and interactions with other pancreatic
cancer risk factors. Fractional polynomials and restricted cubic
splines were used to test for nonlinearity of the dose–response
relationships and to analyze their shape.
Results: Relative to never-smokers, current smokers [OR ¼1.72;
95% confidence interval (95% CI), 1.39–2.12], those inhaling into
the throat (OR¼1.48; 95% CI, 1.11–1.99) or chest (OR¼1.33; 95%
CI, 1.12–1.58), and those using nonfiltered cigarettes (OR ¼ 1.69;
95% CI, 1.10–2.61), were all at an increased pancreatic cancer risk.
Pancreatic cancer risk was highest in current black tobacco smokers
(OR¼2.09; 95% CI, 1.31–3.41), followed by blond tobacco smokers
(OR ¼ 1.43; 95% CI, 1.01–2.04). Childhood exposure to tobacco
smoke relative to parental smoking was also associated with
increased pancreatic cancer risk (OR ¼ 1.24; 95% CI, 1.03–1.49).
Dose–response relationships for smoking duration, intensity,
cumulative dose, and smoking cessation were nonlinear and showed
different shapes by tobacco type. Effect modification by family
history of pancreatic cancer and diabetes was likely.
Conclusions: This study reveals differences in pancreatic cancer
risk by tobacco type and other habit characteristics, as well as
nonlinear risk associations.
Impact: This characterization of smoking-related pancreatic
cancer risk profiles may help in defining pancreatic cancer highrisk
populations.},
publisher = {AACR},
title = {Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships},
doi = {10.1158/1055-9965.EPI-19-1027},
author = {Molina Montes, María Ester and Van Hoogstraten, L and Gomez-Rubio, P and Löhr, M and Sharp, L and Molero, X and Márquez, M and Michalski, CW and Farré, A and Perea, J and O'Rorke, M and Greenhalf, W and Ilzarbe, L and Tardon, A and Gress, TM and Barberà, VM and Crnogorac-Jurcevic, T and Muñoz-Bellvis, L and Domínguez-Muñoz, E and Balsells, J and Costello, E and Iglesias, M and Kleeff, J and Kong, B and Mora, J and O'Driscoll, D and Poves, I and Scarpa, A and Wu, J and Ye, W and Hidalgo, M and Carrato, A and Lawlor, R and Real, FX and Malats, N},
}