@misc{10481/110319,
year = {2020},
url = {https://hdl.handle.net/10481/110319},
abstract = {We report on the formation of a triazolopyrimidine derivative ligand, 7-amino-5-methyl-1,2,4-triazolo[1,5-a]pyrimidine (7-amtp), and a new family of coordination compounds based on this ligand and zinc as metal ion, synthesized by conventional routes. These materials possess different mononuclear structures, namely [ZnCl2(7-amtp)2] (1), [Zn(7-amtp)2(H2O)4](NO3)2·2(7-amtp)·6H2O (2) and [Zn(7-amtp)2(H2O)4](SO4)·1.5H2O (3) derived from the use of different zinc (II) salts, in such a way that the counterions govern the crystallization to a large extent. These compounds present and show variable luminescent properties based on ligand-centred charge transfers which have been deeply studied by Time Dependent Density Functional Theory (TD-DFT) calculations. When these compounds are transferred to solution, preserving complex entities as corroborated by NMR studies, they present interesting anti-diabetic and anti-parasitic capabilities, with a comparatively higher selectivity index than other previously reported triazolopyrimidine-based materials. The results derived from in vivo experiments conducted in mice also confirm their promising activity as anti-diabetic drug being capable of dropping glucose levels after oral administration. Therefore, these new materials may be considered as excellent candidates to be further investigated in the field of luminescent coordination compounds with biomedical applications.},
organization = {Junta de Andalucía (Spain) (project number FQM-195, FQM-394 and FQM-1484) and the Spanish Ministry of Science, Innovation and Universities (MCIU/AEI/FEDER, UE) (PGC2018-102052-A-C22 and PGC2018-102052-B-C21) (University Faculty Training Plan – FPU Grants).},
title = {Anti-diabetic and anti-parasitic properties of a family of luminescent zinc coordination compounds based on the 7-amino-5-methyl-1,2,4-triazolo[1,5- a]pyrimidine ligand},
doi = {https://doi.org/10.1016/j.jinorgbio.2020.111235},
author = {Esteban Parra, Ginés Miguel and San Sebastián, Eider and Cepeda, Javier and Sánchez González, Cristina and Rivas García, Lorenzo and Llopis González, Juan and Aranda Ramírez, Pilar and Sánchez Moreno, Manuel and Quirós Olozábal, Miguel and Rodríguez Diéguez, Antonio},
}