@misc{10481/110211,
year = {2021},
url = {https://hdl.handle.net/10481/110211},
abstract = {Edible flowers are being used as a new ingredient in modern gastronomy. Recently, these products have also
gained interest as an important source of phenolic compounds with potential for biomedical applications. The
present work studied a methanolic extract of Rosa x hybrida in which 35 individual phenolic compounds were
identified. The extract has been evaluated for its antiproliferative properties in ovarian carcinoma cells. Results
showed that the antiproliferative effect was associated with the induction of autophagy and apoptosis with the
concomitant ROS increase probably related to mitochondria dysfunction. These antiproliferative effects might be
associated with some components of the extract such as quercetin. The extract did not induce damage in healthy
cells and that it was able to improve the wound healing activity. The present study also evaluated the properties
of the mentioned extract in vivo in C. elegans. Tests demonstrated a lack of toxicity in the worm model. Promising
results have been obtained in transgenic strains of C. elegans that produce human beta amyloid peptide, suggesting
the possible utility of the extract from the point of view of Alzheimer disease. Altogether, results suggest
that Rosa x hybrida extracts could be a new tool for the development of functional foods.},
organization = {This work
was supported by the Applied Molecular Biosciences Unit (UCIBIO)
which is financed by national funds from FCT (UIDB/04378/2020), LRG
(Inn-Indigo 00002/2015 RA Detect), CRR (SFRH/BPD/124612/2016),
LRR (PTDC/NAN-MAT/31100/2017). María D. Navarro-Hortal and
Jose M. Romero-M´arquez are FPU fellows from the Spanish Ministry of
Educaci´on y Formaci´on Profesional.},
publisher = {Elsevier},
title = {Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease},
doi = {https://doi.org/10.1016/j.fct.2021.112018},
author = {Rivas García, Lorenzo and Quiles Morales, José Luis and Roma-Rodrigues, Catarina and Raposo, Luis and Navarro Hortal, María Dolores and Romero Márquez, José Manuel and Esteban-Muñoz, Adelaida and Varela López, Alfonso and Carrera García, Laura and Cianciosi, Danila and Forbes Hernández, Tamara Yuliett and Battino, Maurizio and Llopis González, Juan and Fernandes, Alexandra and Baptista, Pedro and Sánchez González, Cristina},
}