@misc{10481/110138,
year = {2026},
month = {2},
url = {https://hdl.handle.net/10481/110138},
abstract = {Objective: Our aim was to analyse the serotypes, vaccination and risk factors associated with in-hospital mortality in patients diagnosed with invasive pneumococcal disease (IPD) in two hospitals in Spain. Methods: A retrospective cohort study (2015–2024). Inclusion criteria were adults with IPD and with a serotyped sample registered in our microbiology services. Data were obtained through electronic medical records. The main exposure was pneumococcal vaccination, and the main outcome was in-hospital mortality. Bivariate, multivariable, and survival analyses were performed using R. Results: A total of 188 patients with IPD were included. The most frequent serotypes were 8, 3, 22F, 9 N and 11A. No previous pneumococcal vaccination was shown in 106 (58.6 %) patients. More than 30 % of serotypes were not included in the pneumococcal vaccines currently used in Spain. In-hospital mortality occurred in 27 (14.4 %) patients. Cox regression models showed older age (HR = 1.05, 95 %CI: 1.02–1.08), living in long-term care facilities (HR: 3.27, 95 %CI: 1.36–7.82), septic shock at admission (HR = 2.71; 95 %CI: 1.30–5.67), intensive care admission (HR = 2.64; 95 %CI: 1.53–4.57) and no previous pneumococcal vaccination (HR = 2.14; 95 %CI: 1.86–2.47) as the main factors associated with higher in-hospital mortality due to IPD. Conclusions:
Low frequency of pneumococcal vaccination uptake in adult patients with IPD was demonstrated. Older age, living in long-term care facilities, dependency, septic shock at admission, and no previous pneumococcal vaccination were associated with higher in-hospital mortality. Immunization strategies should imperatively be optimised so as to reduce mortality from IPD.},
organization = {Universidad de Granada/CBUA - (Funding for open access charge)},
publisher = {Elsevier},
keywords = {Streptococcus pneumoniae},
keywords = {Pneumococcal disease},
keywords = {Pneumococcal vaccine},
title = {Evolution of pneumococcal serotypes, vaccination uptake, and prognosis of invasive pneumococcal disease: A 9-year multicentre cohort study in Granada (Andalusia, Spain)},
doi = {10.1016/j.idnow.2026.105244},
author = {Marín-Caba, Elvira and Reinoso Camino, Mario Enrique and Chueca Porcuna, Natalia and Cobo, Fernando and Valero Ubierna, Carmen and Enríquez Maroto, María Francisca and Rivera Izquierdo, Mario and Jiménez Moleón, José Juan},
}