@misc{10481/110033,
year = {2019},
month = {5},
url = {https://hdl.handle.net/10481/110033},
abstract = {In the field of liver transplantation, the demand for adequate allografts greatly exceeds the supply. Therefore, expanding the
donor pool to match the growing demand is mandatory. The present review summarizes current knowledge of the pathophysi-
ology of ischemia/reperfusion injury in steatotic grafts, together with recent pharmacological approaches aimed at maximizing
the utilization of these livers for transplantation. We also describe the preclinical models currently available to understand the
molecular mechanisms controlling graft viability in this specific type of donor, critically discussing the heterogeneity in animal
models, surgical methodology, and therapeutic interventions. This lack of common approaches and interventions makes it
difficult to establish the pathways involved and the relevance of isolated discoveries, as well as their transferability to clinical
practice. Finally, we discuss how new therapeutic strategies developed from experimental studies are promising but that further
studies are warranted to translate them to the bedside.},
organization = {Ministerio de Economía y Competitividad, Madrid, Spain (SAF2015-64857-R)},
organization = {Instituto de Salud Carlos III (FIS PI17/00012)},
organization = {European
Union (Fondos FEDER, “una manera de hacer Europa”)},
organization = {Centres
de Recerca de Catalunya Program/Generalitat de Catalunya},
organization = {Secretaria d’Universitats i Recerca del Departament d’Economia i
Coneixement (2017-SGR-551 & 2017-SGR-517),
Barcelona, Spain.},
organization = {Instituto de Salud
Carlos III},
publisher = {Wiley},
title = {Use of steatotic grafts in liver transplantation: current status},
doi = {10.1002/lt.25430},
author = {Álvarez Mercado, Ana Isabel and Gulfo, Jose and Romero-Gómez, Manuel and Jiménez Castro, Mónica B. and Gracia-Sancho, Jordi and Carmen, Peralta},
}