@misc{10481/109796,
year = {2021},
url = {https://hdl.handle.net/10481/109796},
abstract = {The design of new strategies to increase the effectiveness of the antibacterial treatments is a main goal in public
health. So, the aim of the study was to achieve a local antibacterial directed therapy as novel alternative allowing
both, the delivery of the drug at the target, while minimizing undesirable side effects, thus anticipating an
enhanced effectiveness. Hence, we have developed an innovative nanoformulation composed by biomimetic
magnetic nanoparticles functionalized with the antimicrobial peptide AS-48 and its potential against Grampositive and Gram-negative bacteria, either by itself or combined with magnetic hyperthermia has been investigated. Besides, the physical properties, binding efficiency, stability and mechanism of action of this nanoassembly are analyzed. Remarkably, the nanoassembly has a strong bactericidal effect on Gram-positive bacteria,
but surprisingly also on E. coli and, finally, when combined with magnetic hyperthermia, on P. aeruginosa and
K. pneumoniae. The results obtained represent a breakthrough since it allows a local treatment of infections,
reducing and concentrating the dose of antimicrobial compounds, avoiding secondary effects, including the
resistance generation and particularly because the combination with magnetic hyperthermia helps sensitizing
resistant bacteria to the bactericidal effect of AS-48. Thus, this new formulation should be considered a promising
tool in the antibacterial fight.},
organization = {Ministerio de Economía y Competitividad, CGL2016-76723},
organization = {Instituto de Salud Carlos III, PI20/01658 project},
organization = {Junta de Andalucía, FEDER 2014–2020 (A1-FQM-341-UGR18, C-FQM-497-UGR18, A-BIO-376-UGR18)},
organization = {Plan Andaluz de Investigación, Desarrollo e Innovación, P20_00208, P20_00339 and P20_00346},
organization = {University of Granada, PPJIB2019-01},
organization = {Ministerio de Educación, Cultura y Deporte (Spain), FPU16_04580},
organization = {Federation of European Microbiological Societies, FEMS-GO-2020-201},
publisher = {Elsevier},
keywords = {Biomimetic magnetic nanoparticles},
keywords = {AS-48},
keywords = {Magnetic hyperthermia},
title = {Antibacterial directed chemotherapy using AS-48 peptide immobilized on biomimetic magnetic nanoparticles combined with magnetic hyperthermia},
doi = {10.1016/j.ijbiomac.2021.08.110},
author = {Jabalera Ruz, Ylenia María and Montalbán López, Manuel and Vinuesa-Rodriguez, Juan José and Iglesias Salto, Guillermo Ramón and Maqueda Abreu, Mercedes and Jiménez López, Concepción},
}