@misc{10481/109768,
year = {2015},
url = {https://hdl.handle.net/10481/109768},
abstract = {Purpose

Fructooligosaccharides (FOS) are used as functional foods due to their prebiotic effects. Intestinal anti-inflammatory activity has been established in most, but not all, studies in animal models of colitis, using mainly chemically induced inflammation. Our goal was to test the effect of FOS (degree of polymerization 2–8) in the chronic, lymphocyte-driven CD4+ CD62L+ T cell transfer model of colitis.
Methods

Colitis was induced by transfer of CD4+ CD62L+ T cells to C57BL/6J Rag1−/− mice. FOS (75 mg day−1) was administered by gavage as a post-treatment. Three groups were established: non-colitic (NC), colitic control (C, CD4+ CD62L+ transferred mice treated with vehicle) and colitic+FOS (C+FOS, similar but treated with FOS). Mice were killed after 13 days.
Results

Treatment of mice with FOS ameliorated colitis, as evidenced by an increase in body weight, a lesser myeloperoxidase and alkaline phosphatase activities, a lower secretion of proinflammatory cytokines by mesenteric lymph node cells ex vivo (IFN-γ, IL-17, and TNF-α), and a higher colonic expression of occludin (C+FOS vs. C, p < 0.05). Increased relative abundance of lactic acid bacteria was observed in FOS-treated mice (p < 0.05).
Conclusions

FOS exert intestinal anti-inflammatory activity in T lymphocyte-dependent colitis, suggesting it may be useful in the management of inflammatory bowel disease in appropriate conditions.},
organization = {Fundación Ramón Areces},
organization = {Ministerio de Economía y Competividad (SAF2008-01432, AGL2008-04332, SAF2011-22922, SAF2011-22812)},
organization = {Junta de Andalucía (CTS164, CTS6736)},
organization = {Ministery of Education},
organization = {Instituto de Salud Carlos III},
publisher = {Springer Nature},
keywords = {Fructooligosaccharides},
keywords = {Prebiotic},
keywords = {Colitis},
title = {Fructooligosaccharides exert intestinal anti-inflammatory activity in the CD4+ CD62L+ T cell transfer model of colitis in C57BL/6J mice},
doi = {10.1007/s00394-015-0962-6},
author = {Capitán-Cañadas, Fermín and Ocón, Borja and Aranda Clemente, Carlos José and Anzola, Andrea and Suárez Ortega, María Dolores and Zarzuelo Zurita, Antonio and Sánchez De Medina López-Huertas, Fermín and Martínez Augustín, María Olga},
}