@misc{10481/109573,
year = {2025},
month = {9},
url = {https://hdl.handle.net/10481/109573},
abstract = {Background and objective: In Boron Neutron Capture Therapy, treatment planning is based on a weighted dose in which dose components are weighted with different biological effectiveness (RBE) factors. The most important one for the tumor dose is the compound dependent biological effectiveness (CBE) factor which weighs the boron dose. This was established for brain tumors from radiobiological experiments and has been extrapolated to the more recent application of BNCT to head and neck cancers. The purpose of this work is to study the validity of this assumption.
Methods: Two cell lines, CAL-33 (head and neck squamous cell carcinoma) and A172 (Glioblastoma Multiforme), were irradiated with a very pure thermal-equivalent neutron beam after BPA incubation, and the surviving fraction of cells after irradiation was determined by clonogenicity assays.
Results: The Compound Biological Effectiveness of both cell lines is similar, although for head and neck carcinoma, 10% higher values are systematically found. In addition to this, radiobiological coefficients for the different dose components (photon, neutron and boron) of BNCT in both cell lines are provided.},
organization = {Spanish Fundación Científica de la Asociación Española contra el Cáncer, grant INNOV223579PORR; La Caixa Foundation, grant CC21-10047; Instituto de Salud Carlos III (ISCIII), grant AES-DTS22-00147; the Spanish MICIU/AEI/10.13039/5011000110 under project No. PID2020.117969RB.I00299 and the donors of the University Chair “Neutrons for Medicine”.},
publisher = {MDPI},
keywords = {Compound biological effectiveness},
keywords = {BNCT},
keywords = {Boronophenylalanine},
title = {Comparison of the Biological Response of a Head and Neck Carcinoma and a Glioblastoma Cell Line Under Neutron Irradiation with BPA Administration},
doi = {10.3390/biology14091252},
author = {Álvarez-Rodríguez, Patricia and Méndez-Malagón, Cristina and Porras Quesada, María Isabel and Pedrosa-Rivera, María and Köster, Ulli and Porras Sánchez, José Ignacio and Praena Rodríguez, Antonio Javier and Estrada, Rocío and Pérez-Fuentes, Leonor and Osorio Ceballos, Juan Luis and Ruiz Ruiz, María Carmen and Sancey, Lucie and Ruiz Magaña, María José},
}