@misc{10481/109026,
year = {2020},
month = {1},
url = {https://hdl.handle.net/10481/109026},
abstract = {This cross-sectional study investigates the relationship between the shed form of the Klotho protein (S-Klotho) in plasma, and cardiometabolic risk in healthy, sedentary adults. The study subjects were 214 healthy, sedentary adults (~64% women). Data were collected during the baseline assessments of two randomized controlled trials: The FIT-AGEING study (n=74 [~50% women] middle-aged adults aged 40-65 years) and the ACTIBATE study (n=140 [~70% women] young adults aged 18-25 years). A sex-specific cardiometabolic risk score was calculated for each subject based on waist circumference, systolic and diastolic blood pressure, and plasma glucose, high-density lipoprotein cholesterol and triglycerides. A significant inverse relationship was detected between S-Klotho and the cardiometabolic risk score of both the middle-aged men and women (β=-0.658, R2=0.433, P<0.001 and β=-0.442, R2=0.195, P=0.007) which persisted after adjusting for actual age, energy intake, and VO2max. No significant association was found between S-Klotho and cardiometabolic risk score for the young, healthy adults (P>0.5), nor for the young, healthy men and women when analysed separately (all P>0.1). In conclusion, in healthy, sedentary, middle-aged adults, but not in young, healthy, sedentary adults, higher plasma S-Klotho concentrations are associated with a lower cardiometabolic risk score.},
organization = {Spanish Ministry of Economy and Competitiveness, PI13/01393, DEP2016-79512-R},
organization = {European Regional Development Funds (ERDF)},
organization = {Spanish Ministry of Education, FPU14/04172},
organization = {Spanish Ministry of Education and Science, Red EXERNET DEP2005-00046},
organization = {Fundación Iberoamericana de Nutrición, Red SAMID RD16/0022},
organization = {AstraZeneca HealthCare Foundation},
organization = {University of Granada Plan Propio de Investigación 2016 and Plan Propio de Investigación 2018 and 2019},
organization = {Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, ERDF: ref. SOMM17/6107/UGR},
publisher = {Impact Journals},
keywords = {Aging},
keywords = {Biomarker},
keywords = {Cholesterol},
title = {Relationship between plasma S-Klotho and cardiometabolic risk in sedentary adults},
doi = {10.18632/aging.102771},
author = {Amaro Gahete, Francisco José and Jurado Fasoli, Lucas and Sánchez Delgado, Guillermo and García Lario, José Vicente and Castillo Aguayo, Manuel José and Ruiz Ruiz, Jonatan},
}