@misc{10481/108607,
year = {2025},
month = {10},
url = {https://hdl.handle.net/10481/108607},
abstract = {Background: Lactoferrin in saliva has been proposed as a possible diagnostic biomarker for Alzheimer's disease, as it is associated with ß-amyloid load in the brain. The aim of this study was to find out whether there is an association between salivary lactoferrin and cerebral ß-amyloid load and the involvement of periodontal disease in this possible connection. Material and methods: Six exploratory comparison groups were designed: participants with mild cognitive impairment (n=50) (positive PET-amyloid with and without periodontal disease and negative PET-amyloid with and without periodontal disease) and cognitively normal older individuals with and without periodontal disease (n=19). All participants were recruited from referral hospitals in Granada, Spain, and from a nursing home in the same socio-economic area as the hospital participants. A salivary lactoferrin determination and a periodontal assessment has been performed in each of the participants. Results: The results show that both having an atypical ß-amyloid load in the brain (PET+) and having periodontal disease are clearly associated with a lower concentration of salivary lactoferrin (p=0.011 and p=0.032), but not with age or gender. Conclusions: In this studio, the positive PET-amyloid and periodontal disease are related independently with lower lactoferrin levels.},
organization = {FEDER Operational Program 2014-2020},
organization = {Regional Government of Andalusia},
publisher = {Medicina Oral S.L.},
keywords = {Alzheimer’s disease},
keywords = {periodontal disease},
keywords = {saliva},
keywords = {lactoferrin},
keywords = {amyloid load.},
title = {Relationship between salivary lactoferrin level and brain amyloid load in periodontal and non-periodontal subjects.},
doi = {10.4317/medoral.27612},
author = {Gil Montoya, José Antonio and Gerez-Muñoz, María José and Triviño-Ibañez, Eva María and Rosel Gallardo, Eva María and Bravo Pérez, Manuel and Romero Fábrega, Juan Carlos and Morales Santana, Sonia and Gómez Río, Manuel},
}