@misc{10481/108602,
year = {2025},
month = {9},
url = {https://hdl.handle.net/10481/108602},
abstract = {Introduction: Increases in brain -amyloid protein (A) levels have been demonstrated in animal models following oral inoculation of periodontopathogens or their enzyme gingipain. We investigated the association between periodontitis and brain A protein levels in mild cognitive impairment (MCI). Methods: An observational study was designed. All participants underwent a periodontal examination and an amyloid-PET scan. Subsequently, the following groups were established: MCI and suspected Alzheimer disease (AD) (MCI/A+ group) (n = 45); MCI and suspected non-AD pathology (MCI/A— group) (n = 59); cognitively healthy elderly individuals 
Results: Patients with moderate-severe periodontitis had a higher risk of abnormal accumulation of A in the brain, with an odds ratio (OR) of 3.30 (95% confidence interval [CI], 1.30—8.26) when comparing patients from the MCI/A+ and MCI/A— groups, and an OR of 4.94 (95% CI, 1.65—14.84) when comparing the MCI/A+ group against the non-MCI/A— group. Conclusions: Our findings suggest that periodontal disease may be associated with anomalous accumulation of cerebral A protein in older people, independently of cognitive impairment.},
organization = {AGUEDA study (Ref: I+ D+ iRTI2018-095284-J-I00; 2018)},
publisher = {Elsevier},
keywords = {Periodontal disease},
keywords = {Alzheimer disease},
keywords = {Beta-amyloid},
keywords = {Mild cognitive impairment},
keywords = {Amyloid-PET scan},
title = {Periodontal disease and brain amyloid pathology in mild cognitive impairment},
doi = {10.1016/j.nrleng.2025.07.008},
author = {Gil Montoya, José Antonio and Gerez-Muñoz, M.J. and Triviño-Ibañez, Eva María and Carrera Muñoz, Ismael and Bravo Pérez, Manuel and Rashki, Mahsa and Solís Urra, Patricio and Esteban Cornejo, Irene and Gómez Río, Manuel},
}