@misc{10481/108536,
year = {2025},
month = {8},
url = {https://hdl.handle.net/10481/108536},
abstract = {The co-occurrence of central sensitization syndromes (CSS) and post-traumatic symptoms (PTSS) or
post-traumatic stress disorder (PTSD) exacerbates impairment, and treatment is unsatisfactory in
many cases. This systematic review and meta-analysis examined the effectiveness of psychological
therapy in individuals with CSS and comorbid PTSS/PTSD. A search of Medline, PsycInfo, Web of
Science, Pubmed, and Scopus databases (2000 to 2023) was conducted following PRISMA guidelines.
Nineteen articles were selected, including nine for meta-analysis. The main psychological therapies
were pain-focused cognitive-behavioral therapy (P-CBT), and trauma-focused interventions, mainly
written emotional disclosure (WED) and emotional awareness and expression therapy (EAET). Both
EAET and P-CBT showed potential benefits in improving pain severity (specially EAET), PTSS/PTSD,
emotional distress, fatigue, sleep disturbances, CSS-related symptoms, and quality of life. Overall, no
significant differences were found between the two interventions. The meta-analysis revealed a large
effect size for EAET in reducing pain and emotional distress; however, most comparison were against
inactive controls, so results should be interpreted cautiously. These findings underscore the importance
of distinguishing CSS patients with PTSS/PTSD. Tailored treatments such as EAET can address the
additive impact of these conditions and contribute to improving patients’ quality of life.},
organization = {Spanish Ministry of Science and Innovation and Spanish State Research Agency PID2019-109612GB-I00},
publisher = {Nature portfolio},
keywords = {Psychological intervention},
keywords = {Central sensitization syndromes},
keywords = {Post-traumatic stress disorder},
title = {Psychological intervention in patients with central sensitization syndromes and comorbid psychosocial trauma: a systematic review and meta-analysis},
doi = {10.1038/s41598-025-16074-6},
author = {Maire, Coralie and Sánchez, Ana. I. and Ventura-Lucena, José María and Miró Morales, María Elena and Martínez, M. Pilar},
}