@misc{10481/108488,
year = {2025},
month = {11},
url = {https://hdl.handle.net/10481/108488},
abstract = {To evaluate whether the protons of hemi-protonated C:CH+ base pairs in DNA i-motif structures can be replaced
by silver ions, an i-motif/duplex junction (IDJ) known to be stable at pH 7 was investigated. Interestingly, only the most
accessible out of five C:CH+ pairs in the structure can be converted into a C–AgI
–C base pair, as was derived by 1H NMR
spectroscopy, luminescence spectroscopy, temperature-dependent UV spectroscopy, and isothermal titration calorimetry
(ITC). When more than one silver ion is present per IDJ, dynamic light scattering (DLS) and CD spectroscopy indicate
that the IDJ rearranges into a larger aggregated structure, likely to contain non-canonical silver-mediated base pairs. The
study suggests that—in contrast to earlier reports—the DNA i-motif in general is not compatible with the formation of
contiguous C–AgI
–C pairs.},
organization = {MCIN/AEI/10.13039/501100011033 (Proyecto PID2020-120186RB-I00)},
organization = {Spanish Ministry of Education (Beca Predoctoral FPU23/02032)},
organization = {NSERC (RGPIN-2022-03129)},
publisher = {John Wiley & Sons, Ltd.},
title = {Are i-Motif Structures in DNA Compatible with Cytosine–Ag(I)–Cytosine Base Pairs?},
doi = {10.1002/anie.202519809},
author = {Seiffert, Victoria and López-Chamorro, Carmen and Barceló-Oliver, Miquel and Erbacher, Catharina and Karst, Uwe and Hebenbrock, Marian and Kraatz, Heinz-Bernhard and Galindo, Miguel A. and Müller, Jens},
}