@misc{10481/108293,
year = {2025},
month = {10},
url = {https://hdl.handle.net/10481/108293},
abstract = {Introduction: The efficacy of percutaneous vertebroplasty (PV) versus placebo and conservative treatment (CT) in patients with osteoporotic vertebral fractures (OVFs) has been
debated in recent years. The aim of this study was to conduct an updated systematic review
with a meta-analysis on the efficacy of randomized controlled trials (RCTs) comparing PV
versus placebo and CT in pain relief, functionality and quality of life in patients with OVFs.
Methods: A systematic search was conducted in PubMed, Web of Science, EMBASE, and
CENTRAL, resulting in a total of 15 RCTs. The risk of bias was assessed using the Risk of
Bias v.2 tool. A meta-analysis was performed using the weighted inverse variance method
to analyze the standardized mean difference (SMD) in pain (VAS/NRS scales), functionality
(RMDQ/ODI scales) and quality of life (QUALEFFO scale) in the short (<1 month), medium
(1–6 months) and long terms (≥6 months). Heterogeneity was assessed using I2 and τ
2
.
Subgroup analyses were performed according to the type of control, geographic region,
number of institutions, fracture chronicity, and risk of bias. In addition, sensitivity (leaveone-out) and publication bias (funnel plots and Egger’s tests) analyses were performed.
Results: Overall, PV showed benefits over the combined control groups in pain relief in the
short (SMD: −0.68; 95%CI: −1.28–−0.07), medium (SMD: −0.63; 95%CI: −1.18–−0.07), and
long terms (SMD: −0.59; 95%CI: −1.02–−0.15). No statistically significant differences were
found in functionality and quality of life, although several trends toward significance were
observed favoring PV. Subgroup analyses showed greater advantages of PV at several time
intervals in acute (<8 weeks) OVFs, multicentric trials and studies with a low risk of bias.
There were cues suggestive of potential publication bias in functionality, but not in pain
or quality of life. Conclusions: PV shows significant benefits in pain relief, particularly in
acute OVFs, but its efficacy in terms of functionality and quality of life remains unclear.
These results support the use of PV in appropriately selected patients. However, given the
high heterogeneity found, more controlled, multicenter trials are still required.},
organization = {MICIU/AEI/10.13039/501100011033 - FEDER, European Union (Grant “Proyecto PID2023-151336OB-I00”)},
publisher = {MDPI},
keywords = {Percutaneous vertebroplasty},
keywords = {Vertebral augmentation},
keywords = {Placebo},
title = {Efficacy of Percutaneous Vertebroplasty Versus Placebo and Conservative Treatment in Osteoporotic Vertebral Fractures: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials},
doi = {10.3390/diagnostics15212684},
author = {Laínez Ramos-Bossini, Antonio Jesús and Garrido-Sanz, Francisco and Gea Becerra, Marina and Melguizo Alonso, Consolación and Prados, José},
}