@misc{10481/108262,
year = {2025},
month = {10},
url = {https://hdl.handle.net/10481/108262},
abstract = {Background: The problem of antibiotic resistance is becoming increasingly serious worldwide due to uncontrolled prescription of antibiotics. Studies show conflicting results on
the use or not of antibiotic prophylaxis associated with dental implant placement; its
benefits are unclear, and its use is increasingly questioned. The aim of this randomized
controlled clinical trial (RCT) was to compare early implant failure and postoperative
infectious complications between two groups of healthy, non-penicillin-allergic patients
who received a single prophylactic dose of 2 g amoxicillin versus placebo 1 h before surgery
for implants placed in a single operative field. Methods: A double-blind, parallel-group,
single-center RCT was conducted. One hundred patients met the inclusion criteria and
were randomly assigned to the amoxicillin (n = 50) or placebo (n = 50) group. The primary
endpoints analyzed were early implant failure and the presence of postoperative infection
at 7, 14, 30 and 90 days. The recommendations of the CONSORT 2025 statement for RCT
reporting were followed. Results: A total of 151 implants were placed in 96 patients and
12 implants failed; 6 implants in the antibiotic group (7.7%) and 6 implants in the placebo
group (8.2%), so no statistically significant differences were observed between groups in
the rate of early implant failure. In contrast, 11 implants developed postoperative infection;
2 in the antibiotic group (2.6%) and 9 in the placebo group (12.3%), reaching statistically
significant differences (p = 0.028). Conclusions: The use of antibiotic prophylaxis in healthy
patients is not necessary to prevent early failure of implants placed in a single operative
field; however, the higher rate of infectious complications in patients without antibiotic
therapy still raises a question that requires further investigation.},
publisher = {MDPI},
keywords = {Amoxicillin},
keywords = {Antibiotic prophylaxis},
keywords = {Antibiotic resistance},
title = {Effect of Antibiotic Prophylaxis in Dental Implant Surgery: A Randomized Controlled Clinical Trial},
doi = {10.3390/dj13110500},
author = {Bravo-Olmedo, Fernando and Reyes Botella, Candela and Ocaña-Peinado, Francisco Manuel and Manzano-Moreno, Francisco Javier and Romero Olid, María De Nuria and Olmedo Gaya, María Victoria},
}