@misc{10481/107885,
year = {2026},
month = {1},
url = {https://hdl.handle.net/10481/107885},
abstract = {Activation cross-sections of lutetium and ytterbium radionuclides have been measured by deuteron-induced
nuclear reaction on natYb(d,x) at the GIP ARRONAX (Saint-Herblain, France) cyclotron facility with a beam
energy up to 33 MeV using the stacked-foil activation technique combined with high resolution γ-ray
spectrometry. The measured experimental values enable the extension of the cross-section to higher energies.
As a primary objective, we have focused on the cumulative measurement of the direct and indirect production
routes of the therapeutic radioisotope 177gLu, via 176Yb(d,n) 177 g,mLu and 176Yb(d,p) 177Yb → 177gLu respectively.
Post-irradiation gamma analysis, including a long gamma counting period, was performed to calculate the yield
of the undesirable metastable isotopic impurity 177mLu. The results showed that it was found to be lower than
our detection limit i.e. <0.0005% of 177gLu yield. Thick target yields for all detected radionuclides are also
calculated in this paper. These measurements enabled the estimation of the production yield and isotopic purity
of 177Lu obtained via deuteron-induced nuclear reactions for large production batches using highly enriched
176Yb2O3
samples (>99.5%).},
organization = {MCIN/AEI/10.13039/501100011033 (PID2020-117969RB-I00)},
organization = {EUROfusion Consortium (Grant Agreement No. 101052200)},
organization = {Junta de Andalucía (Projects P20-00665 and B-FQM-156-UGR20, co-funded by FEDER Andalucía 2014–2020)},
organization = {Empresarios Agrupados Internacional, S.A. (funding from CDTI, Misiones DONES-EVO, Contrato UGR-OTRI 5270)},
organization = {Instituto de Salud Carlos III (ISCIII, DTS22/00147)},
organization = {Agence Nationale de la Recherche, France (Programme d’Investissements d’Avenir, ANR-16-IDEX-0007)},
publisher = {Elsevier},
keywords = {177Lu},
keywords = {117mLu},
keywords = {Cross-sections},
title = {Deuteron-induced nuclear reactions to produce 177Lu: Extension of cross-sections data up to 33 MeV and impact on purity},
doi = {10.1016/j.apradiso.2025.112263},
author = {López Melero, María Elena and Nigrón, E. and Haddad, F. and Praena Rodríguez, Antonio Javier},
}