@misc{10481/107757,
year = {2014},
url = {https://hdl.handle.net/10481/107757},
abstract = {This study evaluated the effects of thyroid hormone–
NO interaction on tumor development, vascularization,
vascular endothelial growth factor (VEGF), and aminopeptidase
(AP) activity in a murine model of implanted Lewis’s
carcinoma. Experiments were performed in male CBA-C57
mice. Animals were untreated (controls) or treated with: T4,
the antithyroid drug methimazole, the NO inhibitor L-NAME,
T4+L-NAME, methimazole+NAME, the αvß3 integrin antagonist
tetrac, T4+tetrac, the iNOS inhibitor aminoguanidine
(AG), and T4 + AG; all treatments were for 6 weeks except for
tetrac, administered for the last 11 days. Mice were subcutaneously
inoculated with 1×106 exponentially growing Lewis
carcinoma 3LL cells into the dorsum. Study variables 9 days
later were tumor weight (TW), Hb content, an index of tumor
vascularization, VEGF, and AP activity. T4 produced parallel
increases in TWand angiogenesis. L-NAME reduced TWand
angiogenesis in control, hyperthyroid, and hypothyroid mice,
whereas AG had no effect on these variables. Tetrac arrested
TWin normal and T4-treated mice but did not decrease angiogenesis
in T4-treated animals. Negative correlations were
found between TW and AP activity in tumors from control
hyper- and hypothyroid groups and an inverse relationship
was observed between TWand AP activities in tetrac-treated
mice. T4 enhances TWand angiogenesis, in which NO participates,
but requires activation of integrin αvß3 to promote
carcinogenesis. NO blockade reduces TW, regardless of the
thyroid status. Thyroid hormone negatively modulates AP
activity in the tumor. Accordingly, blockade of the membrane
TH receptor αvß3 integrin reduces TW associated with an
increase in AP activity.},
publisher = {Springer Nature},
title = {Effect of thyroid hormone-nitric oxide interaction on tumor growth, angiogenesis, and aminopeptidase activity},
doi = {10.1007/s13277-014-1726-2},
author = {Carmona Cortes, Javier and Rodríguez Gómez, Isabel and Wangensteen, Rosemary and Banegas, Inmaculada and García Lorca, Ángel and Quesada, Andrés and Osuna, Antonio and Vargas, Félix},
}