@misc{10481/107585,
year = {2025},
month = {9},
url = {https://hdl.handle.net/10481/107585},
abstract = {The holobiont paradigm, conceptualizing host–microbiome assemblages as functionally
integrated entities, has fundamentally altered interpretations of adaptive responses to environmental pressures spanning multiple organizational levels. This review synthesizes the
current knowledge on microbiome-host coevolution, focusing on three key aspects. First, it
examines the evolutionary origins of holobionts from primordial microbial consortia. Second, it considers the mechanistic basis of microbiome-mediated stress resilience in plants
and animals. Finally, it explores the ecological implications of inter-holobiont interactions.
We highlight how early microbial alliances (protomicrobiomes) laid the groundwork for
eukaryotic complexity through metabolic cooperation, with modern holobionts retaining
this plasticity to confront abiotic and biotic stressors. In plants, compartment-specific microbiomes (e.g., rhizosphere, phyllosphere) enhance drought tolerance or nutrient acquisition,
while in animals, the gut microbiome modulates neuroendocrine and immune functions
via multi-organ axes (gut–brain, gut–liver, etc.). Critically, we emphasize the role of microbial metabolites (e.g., short-chain fatty acids, VOCs) as universal signaling molecules
that coordinate holobiont responses to environmental change. Emerging strategies, like
microbiome engineering and probiotics, are discussed as tools to augment stress resilience
in agriculture and medicine. By framing adaptation as a collective trait of the holobiont, this
work bridges evolutionary biology, microbiology, and ecology to offer a unified perspective
on stress biology.},
organization = {MCIU/AEI - ERDF/European Union “A way of making Europe” (Grant PID2021-127623OB-I00)},
publisher = {MDPI},
keywords = {holobiont},
keywords = {microbiome-host coevolution},
keywords = {stress adaptation},
title = {From Microbial Consortia to Ecosystem Resilience: The Integrative Roles of Holobionts in Stress Biology},
doi = {10.3390/biology14091203},
author = {Manzanera Ruiz, Maximino Enrique},
}