@misc{10481/107563,
year = {2025},
month = {3},
url = {https://hdl.handle.net/10481/107563},
abstract = {The importance of crystal surface reactivity of reticular materials is exemplified by exfoliation of nonporous layered zeolitic imidazolate framework Zn(mIm)2·0.5mImH (ZIF-L, mImH = 2-methylimidazole). Sonication of ZIF-L ethanolic suspensions leads to exfoliation of microcrystals along the 2 0 0 planes, giving rise to 1.5 μm wide × 25 nm thick flakes, which we term ZIF-L_exf. ZIF-L_exf exhibits a high reactivity toward hydrolytic degradation of extremely toxic G-type nerve agents, Soman (GD), and simulant diisopropylfluorophosphate (DIFP). The reactivity of the crystal surface of ZIF-L_exf toward P–F bond breakdown gives rise to framework structural degradation, releasing nucleophilic mImH molecules that reactivate organophosphate-inhibited acetylcholinesterase within 10 min. This detoxification process can be taken as a proof of concept for reversing organophosphorous poisoning. More generally, this approach underscores the importance of the crystal surface nature and composition to control the reactivity of reticular materials.},
organization = {“ERDF-EU”},
organization = {Spanish Ministry of Education (FPU23/01844)},
organization = {“European Union NextGenerationEU/PRTR”},
organization = {MCIN/AEI/10.13039/501100011033 (PID2023-147972OB-I00, RYC2021-031249-I)},
publisher = {American Chemical Society},
keywords = {Crystals},
keywords = {Degradation},
keywords = {Exfoliation},
keywords = {Proteins},
keywords = {Reactivity},
title = {Reactive ZIF-L Crystal Surface for Organophosphorous Degradation and Acetylcholinesterase Reactivation},
doi = {10.1021/jacs.5c00382},
author = {Borrego Marin, Emilio and Garrido-Barros, Pablo and Peterson, Gregory W. and Vismara, Rebecca and Carmona Fernández, Francisco Jesús and Barea Martínez, Elisa María and Rodríguez Navarro, Jorge Andrés},
}