@misc{10481/107376,
year = {2025},
month = {9},
url = {https://hdl.handle.net/10481/107376},
abstract = {Background: Rheumatoid arthritis and periodontitis are chronic inflammatory diseases
linked to systemic complications, including increased cardiovascular risk. The impact of
glycemia, lipid profile and atherogenic cardiovascular risk indices in patients with rheumatoid arthritis (RA) and periodontitis, compared to controls, has not yet been evaluated. We
aimed to analyze whether periodontitis acts as an aggravating factor in this relationship.
Methods: In a case–control study, we assessed biochemical, RA-related markers and four
atherogenic indices (Atherogenic Index of Plasma, Castelli Risk Index I, Castelli Risk Index
II, and Triglyceride–Glucose Index). Periodontitis was evaluated using a gingival inflammation index (BOP) and a periodontal severity index (PIRIM). Multiple linear regression
models were used to analyze whether periodontitis had a differential effect in RA cases
versus controls. Results: A total of 46 participants were included (32 RA cases, 14 controls).
Periodontitis was more prevalent among cases (62.5% vs. 28.5%). BOP was significantly
higher in RA patients (p < 0.001) and associated with LDLC (p = 0.031). Both BOP and
PIRIM correlated with higher CRI-1 and CRI-2 values across groups. PIRIM was also linked
to increased LDLC (p = 0.018) and decreased HDLC (p = 0.003). Conclusions: RA and
periodontitis appear to interact synergistically and are associated with a more atherogenic
profile. These findings highlight periodontal health as a potentially modifiable factor in
reducing cardiovascular risk in RA patients.},
organization = {Junta de Andalucía (CTS583)},
publisher = {MDPI},
keywords = {Periodontitis},
keywords = {Cardiovascular Risk},
keywords = {Dyslipidemia},
title = {Periodontitis, Dyslipidemia and Rheumatoid Arthritis: An Additive Model of Cardiovascular Risk},
doi = {10.3390/jcm14196722},
author = {Bonilla, Marcos and Raya Álvarez, Enrique Germán and Bravo, Manuel and Rosel, Eva and Mesa, Francisco},
}