@misc{10481/106960,
year = {2025},
month = {10},
url = {https://hdl.handle.net/10481/106960},
abstract = {Ilicic acid, nerolidol, and 9-hydroxynerolidol are major components of the aerial parts
of Dittrichia viscosa. These components were selectively isolated in multigram quantities
and used as lead compounds to generate diversity in the search for new natural-productderived pesticides. A total of 29 derivatives of these three molecules—some of which are
known natural products—were generated by subjecting these natural products to different transformations. In order to explore potential applications in sustainable biocontrol,
some of the compounds generated were evaluated for plant protection potential against
insect pests (Spodoptera littoralis, Myzus persicae, Rhopalosiphum padi), against the nematode
Meloidogyne javanica, and for their phytotoxic effects on ryegrass (Lolium perenne) and lettuce
(Lactuca sativa). Additionally, their effects against the tick Hyalomma lusitanicum have been
tested. Compound 11 was found to be antifeedant against S. littoralis and nematicidal.
Compounds 3a and 8 were potent antifeedants against R. padi. None of the tested compounds significantly inhibited lettuce growth, and compounds 17, 3, and 3a even promoted
root development. Conversely, compounds 3, 4, 11, 17, and 21a exhibited strong herbicidal
activity on ryegrass. In larvicidal assays against H. lusitanicum, compounds 3, 3a, 11, 17,
29, and 33 were active, with compound 29 being six times more active than the positive
control nootkatone.},
organization = {State Research Agency (PID2024-156361OB-C22)},
publisher = {MDPI},
keywords = {Natural products},
keywords = {Terpenes},
keywords = {Organic synthesis},
title = {Major Components of Dittrichia viscosa (Asteraceae) as a Source of New Pesticides},
doi = {10.3390/molecules 30193950},
author = {Segura Navarro, María José and Quílez Del Moral, José Francisco and Andrés, María Fe de and Valcárcel, Félix and González Coloma, Azucena and Molina Inzunza, Diego O. and Fernández Barrero, Alejandro},
}