@misc{10481/106922,
year = {2025},
month = {10},
url = {https://hdl.handle.net/10481/106922},
abstract = {Copper accumulation in agricultural soils poses environmental challenges by selecting copper-resistant bacteria and also contributing to the co-selection of antibiotic-resistant bacteria. In addition, copper influences bacterial predator-prey interactions, potentially altering microbial ecosystems. Myxococcus xanthus, a soil-dwelling bacterium, preys on other microorganisms, including Sinorhizobium meliloti, a symbiotic nitrogen-fixing bacterium associated with leguminous plants. The role of copper in M. xanthus interactions remains poorly understood, although it accumulates at the predator-prey interface. In this study, we explore the transcriptomic response of M. xanthus to copper stress in both monocultures and co-cultures with S. meliloti. Our analysis identified many myxobacterial copper-regulated transcripts, and studies on mutant strains in some copper-induced genes revealed the role of two efflux pumps in cross-resistance to copper and tetracyclines. These findings provide new insights into the adaptive mechanisms of M. xanthus in response to copper, with implications for the co-selection of antibiotic resistance and the broader impact of copper on microbial community dynamics in soil ecosystems.},
organization = {Grant PID2020-112634GB-I00 (to A.M.M.) funded by MCIN/AEI/10.13039/501100011033.},
organization = {Marie Skłodowska-Curie Action (MSCA) grant LysM Ref. 101106411 (to F.J.M.T.).},
organization = {Funding for open access charge: Universidad de Granada/CBUA.},
publisher = {Elsevier},
keywords = {Copper homeostasis},
keywords = {Antibiotic co-resistance},
keywords = {Bacterial predation},
keywords = {Myxococcus xanthus},
keywords = {Sinorhizobium meliloti},
title = {Global copper response of the soil bacterial predator Myxococcus xanthus and its contribution to antibiotic cross-resistance},
doi = {10.1016/j.micres.2025.128357},
author = {Marcos Torres, Francisco Javier and Pérez Torres, Juana and Torrens González, David and García Pedrosa, Miguel Ángel and Contreras Moreno, Francisco Javier and Moraleda Muñoz, Aurelio},
}