@misc{10481/106861,
year = {2025},
month = {8},
url = {https://hdl.handle.net/10481/106861},
abstract = {Background/Objectives: Patients with chronic hypoparathyroidism are at increased risk
of kidney complications. Also, chronic kidney disease is associated with increased cardiovascular risk. The aim was to analyze the factors that influence kidney function, including
cardiovascular diseases (CVD), in a cohort of patients with chronic hypoparathyroidism.
Methods: This was a retrospective longitudinal study that included 100 patients with
chronic hypoparathyroidism. Results: The estimated glomerular filtration rate (eGFR)
was associated with the duration of disease (p = 0.014). During follow-up, a significant
decrease in eGFR was observed over time (p < 0.001), and changes in the eGFR were
associated with the duration of disease (p < 0.001). We found that the eGFR was lower in
patients with urolithiasis (p = 0.003), hypertension (p < 0.001), type 2 diabetes (p = 0.031)
and dyslipidemia (p < 0.001). In total, 14% of patients had a chronic kidney disease (CKD),
and these patients had a longer duration of disease (p < 0.001). The percentage of patients
with urolithiasis (p = 0.003), nephrocalcinosis (p = 0.008), hypertension (p = 0.005), type
2 diabetes (p < 0.001), dyslipidemia (p < 0.001), coronary heart disease (p = 0.008), and
arrhythmia (p < 0.001) was higher in patients with CKD. Logistic regression models showed
that disease duration was associated with CKD (OR = 1.11; 95% CI [1.03–1.22]; p = 0.008).
We used ROC curves to assess the usefulness of disease duration as a marker of CKD, and
the AUC was 0.850 (95% CI 0.763–0.937, p < 0.001). A duration of disease > 15.5 years
had a sensitivity of 85.7% and a specificity of 71.9% for a diagnosis of CKD. Conclusions:
The duration of disease appears to be a predictor of the presence of renal dysfunction in
patients with chronic hypoparathyroidism. In addition, the coexistence of CVD factors
could result in greater renal damage.},
publisher = {MDPI},
keywords = {chronic hypoparathyroidism},
keywords = {Chronic kidney disease},
keywords = {Cardiovascular disease},
title = {Factors Related to Decline of Renal Function in Patients with Chronic Hypoparathyroidism},
doi = {10.3390/jcm14165732},
author = {López-Mezquita Torres, Elena and García Martín, Antonia and Andreo-López, María del Carmen and Contreras Bolívar, Victoria and García Fontana, Cristina and García-Fontana, Beatríz and Muñoz-Torres, Manuel Eduardo},
}