@misc{10481/106666,
year = {2025},
month = {4},
url = {https://hdl.handle.net/10481/106666},
abstract = {Introduction: Vitamin D deficiency is commonly found among patients with obstructive sleep apnea (OSA). We
aimed to determine the effect of an eight-week interdisciplinary weight loss and lifestyle intervention on
circulating vitamin D levels in patients with moderate-to-severe OSA.
Methods: 89 men were assigned to a usual-care group (n = 49) or an 8-week interdisciplinary weight loss and
lifestyle intervention combined with usual-care (n = 40). Evaluations were conducted at baseline, intervention
endpoint (i.e., 8 weeks), and 6 months post-intervention. Serum 25-hydroxyvitamin D (25(OH)D) was determined using a chemiluminescence immunoassay. Sleep (i.e., sleep efficiency, apnea-hypopnea index [AHI], and
oxygen desaturation index) and body weight and composition (i.e., fat mass, and visceral adipose tissue) variables were also determined.
Results: Serum 25(OH)D concentrations showed an insufficient vitamin D status at baseline, which significantly
increased (all p ≤ 0.034) at intervention endpoint (19 %) and at 6 months after intervention (45 %) in the
intervention group to the point of potentially resolving vitamin D deficiency. Higher serum 25(OH)D concentrations were related to increased sleep efficiency and reduced AHI, oxygen desaturation index, and body weight
and composition variables (all p < 0.001) from baseline to 6 months and from 8 weeks to 6 months after
intervention. These results were also noted from baseline to 8 weeks, except for body composition (all p ≤ 0.007).
Conclusion: The intervention improved and potentially resolved vitamin D deficiency. Together with the
improvement of adverse sleep patterns and body composition parameters, it may be considered as a promising
approach in the treatment of OSA.},
organization = {Spanish Ministry of Education (FPU16/01093; FPU14/04172)},
organization = {Regional Ministry of Economy, Knowledge,
Enterprise and Universities (CECEU) of Andalusia (European Regional
Development Funds, SOMM17/6107/UGR)},
organization = {University of Granada-LoMonaco S.L. Sleep
Research Cathedra},
organization = {University of Granada Plan Propio de Investigación  2016 –Excellence actions: Unit of Excellence on Exercise and
Health (UCEES)},
publisher = {Elsevier B.V.},
keywords = {Obstructive sleep apnea},
keywords = {Obesity},
keywords = {Weight loss},
title = {Impact of weight loss and lifestyle intervention on vitamin D in men with obstructive sleep apnea: The INTERAPNEA trial},
doi = {10.1016/j.sleep.2025.01.011},
author = {Vázquez-Lorente, Héctor and Herrera-Quintana, Lourdes and Ruiz Ruiz, Jonatan and Amaro-Gahete, Francisco J. and Carneiro-Barrera, Almudena},
}