@misc{10481/106544,
year = {2025},
month = {11},
url = {https://hdl.handle.net/10481/106544},
abstract = {Bisphenols and parabens are endocrine-disrupting chemicals widely used in food packaging and personal care products. Early-life exposure to these compounds has
been associated with adverse health effects, but their potential role in modulating the gut microbiota during childhood remains poorly understood. The objective of
this study was to investigate the association between chronic exposure to bisphenols and parabens and gut microbiota diversity, composition, and function in
children. A cross-sectional study in 97 Spanish children aged 4–12 year was conducted. Bisphenols and parabens in hair were quantified using ultra-high performance
liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). Gut microbiota composition was assessed via 16S rRNA gene sequencing, and functional
potential was inferred using PICRUSt2. Associations were explored using linear regression and random forest models, adjusting for age and sex. Total bisphenols and
parabens were detected in 100 % of the children, with median concentrations of 311.33 ng/g and 1904.11 ng/g, respectively. No significant differences in overall gut
microbiota diversity were observed between children with low and high exposure levels to bisphenols and parabens. However, regression models revealed associations between specific microbial genera and individual compounds. Additionally, bisphenol S was negatively associated with a predicted microbial pathway
involved in methionine metabolism. Notably, Lachnospiraceae_UCG-001 emerged as a predictive genus for propylparaben exposure. Although gut microbiota
composition was similar across exposure levels, specific taxa and functional pathways were linked to chronic bisphenol and paraben exposure. These findings support
the need for further research on the health implications of early-life exposure to these endocrine-disrupting chemicals.},
organization = {Instituto de Salud Carlos III (ISCIII) - European Union (project “PI20/01278” and “PI23/01359”)},
organization = {project FEDER-Consejería de Salud
y Familias, Junta de Andalucía (“PE-0250–2019”)},
publisher = {Elsevier Inc.},
title = {Associations between chronic exposure to bisphenols and parabens and gut microbiota in children},
doi = {10.1016/j.envres.2025.122643},
author = {Rodrigo Conde Salazar, Lourdes T. and Bressa, Carlo and Larrosa, Mar and Ramírez, Viviana and Gil-Izquierdo, Ángel and Sánchez Muñoz, Cristóbal and Martínez Burgos, María Alba and Zafra-Gómez, Alberto and Rivas, Ana},
}