@misc{10481/106463,
year = {2025},
month = {8},
url = {https://hdl.handle.net/10481/106463},
abstract = {Alzheimer’s disease (AD) is the most prevalent form of dementia and a major global health
challenge, characterized by progressive cognitive decline and neurodegeneration. Despite
decades of research, there is currently no cure, and available treatments provide only limited
symptomatic relief without halting disease progression. In this context, natural compounds
with multi-targeted biological activities are being explored as potential complementary
therapeutic strategies. Honey, a complex natural substance rich in bioactive phytochemicals, has emerged as a promising candidate due to its antioxidant, anti-inflammatory,
anti-apoptotic, and enzyme-inhibitory properties. This review summarizes the molecular mechanisms underlying the neuroprotective effects of honey in the context of AD,
with a particular focus on its ability to modulate oxidative stress, mitochondrial dysfunction, inflammation, apoptosis, β-amyloid accumulation, tau hyperphosphorylation, and
neurotransmission-related enzymes. Notably, the botanical origin of honey significantly
influences its composition and biological activity, as evidenced by studies on avocado,
manuka, acacia, kelulut, chestnut, coffee, or tualang honeys. While preclinical findings are
encouraging, especially in vitro and in invertebrate and rodent models, clinical validation
is still lacking. Therefore, further research, including well-designed in vivo and human
studies, is needed to clarify the therapeutic relevance of honey in AD. Overall, honey may
represent a promising natural adjunct in the prevention or management of AD, but current
evidence remains preliminary.},
publisher = {MDPI},
keywords = {manuka},
keywords = {tualang},
keywords = {antioxidants},
title = {Honey as a Neuroprotective Agent: Molecular Perspectives on Its Role in Alzheimer’s Disease},
doi = {10.3390/nu17162577},
author = {Navarro Hortal, María Dolores and Romero Márquez, José M. and Ansary, Johura and Hinojosa Nogueira, Daniel José and Montalbán-Hernández, Cristina and Varela López, Alfonso and Quiles Morales, José Luis},
}