@misc{10481/106233,
year = {2024},
month = {10},
url = {https://hdl.handle.net/10481/106233},
abstract = {Regulation of neuroimmune interactions varies across avian species. Little is presently known about the interplay between periphery and central nervous system (CNS) in parrots, birds sensitive to neuroinflammation. Here we investigated the systemic and CNS responses to dextran sulphate sodium (DSS)- and lipopolysaccharide (LPS)-induced subclinical acute peripheral inflammation in budgerigar (Melopsittacus undulatus). Three experimental treatment groups differing in DSS and LPS stimulation were compared to controls. Individuals treated with DSS showed significant histological intestinal damage. Through quantitative proteomics we described changes in plasma (PL) and cerebrospinal fluid (CSF) composition. In total, we identified 180 proteins in PL and 978 proteins in CSF, with moderate co-structure between the proteomes. Between treatments we detected differences in immune, coagulation and metabolic pathways. Proteomic variation was associated with the levels of pro-inflammatory cytokine mRNA expression in intestine and brain. Our findings shed light on systemic impacts of peripheral low-grade inflammation in birds.},
organization = {Charles University supported this study through the grant No. PRIMUS/17/SCI/12, and the Czech Science Foundation through the grants No. 19-20152Y and 24-12477 S. The Czech Ministry of Education, Youth and Sports supported this research through the Inter-ACTION project LUAUS24184 and institutional support No. 260684/2023. Computational resources were supplied by the project “e-Infrastruktura CZ” (e-INFRA CZ LM2018140) supported by the Ministry of Education, Youth and Sports of the Czech Republic.},
publisher = {Elsevier},
keywords = {Cerebrospinal fluid},
keywords = {Dextran sulphate sodium},
keywords = {Endotoxin},
keywords = {Parrot},
keywords = {Plasma},
keywords = {Proteomics},
title = {Subclinical peripheral inflammation has systemic effects impacting central nervous system proteome in budgerigars},
doi = {10.1016/j.dci.2024.105213},
author = {Voukali, Eleni and Gómez Samblás, María Mercedes and Kuttiyarthu Veetil, Nithya and Krajzingrová, Tereza and Tesicky, Martin and Li, Tao and Melepat, Balraj and Vinkler, Michal},
}