@misc{10481/106164,
year = {2025},
month = {7},
url = {https://hdl.handle.net/10481/106164},
abstract = {Alzheimer's disease (AD) is one of the leading causes of disability worldwide.
Alterations in cerebral blood flow (CBF) and blood biomarkers of AD are critical in the
early stages of the disease. Exercise is a promising non-pharmaceutical intervention to
reverse these physiological changes, but the specific mechanisms by which exercise
improves brain health remain unknown. The flADex project aims to examine the acute
effects of different types of exercise on CBF and blood biomarkers of AD in cognitively
normal older adults.
FlADex is a counterbalanced crossover trial that will enroll 20 adults aged 68 to 83 years
with negative brain amyloid status (<12 centiloid) who are non-carriers of APOE e4. All
participants will complete a 30-minute session of each condition in a randomized order:
(i) moderate-intensity aerobic exercise (60–70% of maximum heart rate), (ii) moderate-
intensity resistance exercise (perceived exertion rating: 4–6 points out of 10), and (iii)
resting condition. The primary outcome, CBF, will be assessed using magnetic resonance
imaging at baseline and at three post-condition time points (starting at 20, 27, and 34
minutes). Blood biomarkers of AD (Aβ42, Aβ40, p-tau217, p-tau181, GFAP, NfL) and
growth factors (BDNF, IGF-1) will be measured before and after each condition (at 3, 50,
and 70 minutes). Cognitive outcomes (sequential image memory and Flanker tests) and
mood (POMS questionnaire and Feeling Scale) will be measured before and after the
condition.
This document provides an index of the chapters detailing each of the manuals of
procedures implemented in the flADex Project. The objective of publishing the flADex
manuals of procedures is to enhance the visibility of the procedures conducted across all
phases of the project and to make them openly accessible for consultation by anyone
interested.},
title = {Manual of Procedures Summary of FLADEX project},
author = {Esteban Cornejo, Irene and Martin-Fuentes, Isabel and Solís Urra, Patricio and Fernandez-Gamez, Beatriz and Toval, Angel and Caro-Rus, Alfredo and Coca-Pulido, Andrea and Olvera-Rojas, Marcos and Sanchez-Martinez, Javier and Fernández‐Ortega, Javier and Bellón, Darío and Sánchez-Aranda, Lucía and Sclafani, Alessandro and Marín-Álvarez, José David and Barranco-Moreno, Emilio José and Gómez Río, Manuel and Rodríguez-Palacios, María Teresa},
}